Table 5 Caregiver-reported initial symptoms of MLD individuals by onset type
Initial symptoms (ordered by total) | Overall (n = 32*) | Late infantile (n = 20) | Juvenile (n = 11) |
|---|---|---|---|
By early signs | |||
 Coordination difficulties, n (%) | 24 (75.0) | 18 (90.0) | 6 (54.5) |
 Clonus/Tremor, n (%) | 9 (28.1) | 5 (25.0) | 3 (27.3) |
 Comprehension challenges, n (%) | 9 (28.1) | 2 (10.0) | 6 (54.5) |
 Change in Behavior/Personality, n (%) | 6 (18.8) | 1 (5.0) | 5 (45.5) |
 Vision Issues, n (%) | 3 (9.4) | 3 (15.0) | 0 (0.0) |
By symptom type | |||
 Physical symptoms (coordination difficulties, clonus/tremor, vision issues) | 28 (87.5) | 19 (95.0) | 8 (72.7) |
 Cognitive symptoms (comprehension challenges, change in behavior/personality) | 10 (31.3) | 2 (10.0) | 7 (63.6) |
By developmental signs | |||
 Development delays | 7 (21.9) | 5 (25.0) | 1 (9.1) |
 Developmental regression | 11 (34.4) | 5 (25.0) | 6 (54.5) |
 Developmental stagnation | 7 (21.9) | 6 (30.0) | 1 (9.1) |