Table 1 Characteristics of study participants and treatment outcome.
From: Aripiprazole treatment for temper outbursts in Prader–Willi syndrome
ID | Sex | Age | Genetic subtype | Symptoms baseline | CGI | Course | CGI-I | Dose | Side effects | BMI baseline kg/m2 | BMI after 6 month kg/m2 | Psychiatric medication | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | f | 28 | Unknown | Perseveration, obsessions. Treated with risperidone but severe daytime sleepiness. After stop of risperidone: massive temper outbursts | 7 | Decrease of intensity and frequency of outbursts | 2 | 5 mg | Daytime sleepiness but less than with risperidone | 22.19 | 22.60 | Medication changed to dose in the evening to improve daytime sleepiness | |
2 | m | 31 | delPWS 2 | Irritability, temper outbursts | 6 | Irritability improved, nearly no more temper outbursts | 1 | 5 mg | Daytime sleepiness | 21.11 | 21.66 | Medication changed to dose in the evening to improve daytime sleepiness | |
3 | m | 30 | delPWS 1 | Irritability, temper outbursts | 6 | Slight reduction in frequency and intensity of outbursts | 3 | 5 mg | Mild increase of daytime sleepiness | 26.12 | 24.82 | ||
4 | m | 30 | unknown | Irritability with severe temper outbursts, perseverations, obsessions, mistrust, | 6 | Improvement of outbursts, obsessions, mistrust | 1 | 10 mg | 26.34 | 26.96 | risperidone 4 mg sertraline 100 mg (stopped at start of aripiprazole) | After 1 month significant improvement, then deterioration. After increase of dose again significant improvement | |
5 | f | 35 | unknown | Irritability with temper outbursts | 6 | Improvement of irritability and temper outbursts | 2 | 10 mg | 21.78 | 20.47 | milnacipram 50 mg (stopped at start of aripiprazole) | ||
6 | m | 52 | delPWS 1 | Irritability with temper outbursts with destruction of property. Conflicts with people | 5 | Improvement of irritability and temper outbursts | 3 | 10 mg | Mild increase of daytime sleepiness | 26.35 | 25.33 | ||
7 | f | 46 | delPWS 2 | Irritability with temper outbursts | 6 | Improvement of irritability and outbursts | 2 | 5 mg | Daytime sleepiness | 25.11 | / | Stopped because of side effects | |
8 | m | 25 | delPWS | Irritability, temper outbursts with physical attacks | 6 | No conflicts anymore | 1 | 5 mg | 22.43 | 22.57 | sertraline 50 mg risperidone 0.5 mg | Under Sertraline and Risperidone no treatment success, change of Risperidone to Aripiprazole lead to a massive improvement | |
9 | f | 37 | Unknown | Irritability with temper outbursts | 6 | No change | 4 | 5 mg | 39.48 | / | Stopped because no success | ||
10 | m | 44 | delPWS 2 | Irritability with temper outbursts | 5 | Decrease of frequency & intensity of outbursts | 2 | 5 mg | Daytime sleepiness | 24.91 | / | Stopped because of side effects |