Table 3 Prevalence of B12 deficiency stratified by age groups
From: Vitamin B12 in Leber hereditary optic neuropathy mutation carriers: a prospective cohort study
Total LHON cohort | LHON patients | Asymptomatic LHON carriers | p value | |
|---|---|---|---|---|
n/N (%) | n/N (%) | n/N (%) | ||
(a) B12 deficiency in LHON cohort | ||||
< 20 y | 4/62 (6.5) | 2/32 (6.3) | 2/30 (6.7) | n.s |
20–39 y | 23/84 (27.4) | 15/57 (26.3) | 8/27 (29.6) | n.s |
40–59 y | 20/79 (25.3) | 11/46 (23.9) | 9/33 (27.3) | n.s |
≥ 60 y | 4/19 (21.1) | 2/12 (16.7) | 2/7 (28.6) | n.s |
Total | 51/244 (20.9) | 30/147 (20.4) | 21/97 (21.6) | n.s |
Total LHON cohort | German population [22] | p value | |
|---|---|---|---|
n/N (%) | n/N (%) | ||
(b) B12 deficiency in LHON cohort compared to the general population | |||
< 65 y | 48/234 (20.5) | (5–7) | 0.002** |
≥ 65 y | 3/10 (30) | (10–30) | n.s |