From: Consensus guidelines for diagnosis and management of anemia in epidermolysis bullosa
Intravenous iron preparation | Maximum recommended dose | Duration of infusion |
---|---|---|
Low molecular weight iron dextran* | Test dose: administer prior to start iron dextran therapy and observe for 15–30 min  Infants ≥ 4 months and < 10 kg: 10 mg (0.2 ml)  Children 10–20 kg: 15 mg (0.3 ml)  Children > 20 kg and adults 25 mg (0.5 ml) | – |
Therapeutic dose IV Â 20Â mg/kg, max 1000Â mg/dose | 1Â h | |
Therapeutic dose IM  Infants ≥ 4 months < 5 kg:25 mg (0.5 ml)/day  Children 5–10 kg: 50 mg (1 mL)/day  Children > 10 kg and adults 100 mg (2 mL)/day | – | |
Iron sucrose | Test dose: not necessary  Children ≥ 2 years of age: 5–7 mg/kg/dose; maximum initial dose: 100 mg/dose. Maintenance dosing 5 to 7 mg/kg/dose every 1 to 7 days until total replacement dose achieved; maximum single dose: 300 mg/dose  Adults: 100–300 mg per dose (frequency and duration of therapy may vary); repeated until hematologic parameters or total iron requirements are met | 30–90 min |
Adults: 500Â mg once weekly for 2Â weeks | 4Â h | |
Ferric carboxymaltose | Safety and efficacy in children not established | Â |
Adults: < 50 kg  15 mg/kg IV in 2 doses separated by at least 7 days  Not to exceed cumulative dose 1500 mg per course Adults: ≥ 50 kg  750 mg IV in 2 doses separated by at least 7 days; not to exceed cumulative dose of 1500 mg per course  Alternatively, may administer 15 mg/kg IV as a single dose; not to exceed 1000 mg | Minimum 15 min (100 mg/min) | |
Ferumoxytol | Safety and efficacy in children not established | Â |
Adults: 510 mg × 2 doses 3 to 8 days apart 1.02 g over ~ 30 min as a single dose | 15–30 min | |
Sodium ferric gluconate | Children ≥ 6 years of age: 1.5 mg/kg elemental Fe IV do not exceed 125 mg | 1 h |
Adults: 125 mg q treatment × 8 doses |  |