Table 9 Intravenous iron formulations and dosing

Low molecular weight iron dextran*

Test dose: administer prior to start iron dextran therapy and observe for 15–30 min

 Infants ≥ 4 months and < 10 kg: 10 mg (0.2 ml)

 Children 10–20 kg: 15 mg (0.3 ml)

 Children > 20 kg and adults 25 mg (0.5 ml)

–

Therapeutic dose IV

 20 mg/kg, max 1000 mg/dose

1 h

Therapeutic dose IM

 Infants ≥ 4 months < 5 kg:25 mg (0.5 ml)/day

 Children 5–10 kg: 50 mg (1 mL)/day

 Children > 10 kg and adults 100 mg (2 mL)/day

–

Iron sucrose

Test dose: not necessary

 Children ≥ 2 years of age: 5–7 mg/kg/dose; maximum initial dose: 100 mg/dose. Maintenance dosing 5 to 7 mg/kg/dose every 1 to 7 days until total replacement dose achieved; maximum single dose: 300 mg/dose

 Adults: 100–300 mg per dose (frequency and duration of therapy may vary); repeated until hematologic parameters or total iron requirements are met

30–90 min

Adults: 500 mg once weekly for 2 weeks

4 h

Ferric carboxymaltose

Safety and efficacy in children not established

Adults: < 50 kg

 15 mg/kg IV in 2 doses separated by at least 7 days

 Not to exceed cumulative dose 1500 mg per course

Adults: ≥ 50 kg

 750 mg IV in 2 doses separated by at least 7 days; not to exceed cumulative dose of 1500 mg per course

 Alternatively, may administer 15 mg/kg IV as a single dose; not to exceed 1000 mg

Minimum 15 min (100 mg/min)

Ferumoxytol

Safety and efficacy in children not established

Adults: 510 mg × 2 doses 3 to 8 days apart

1.02 g over ~ 30 min as a single dose

15–30 min

Sodium ferric gluconate

Children ≥ 6 years of age: 1.5 mg/kg elemental Fe IV do not exceed 125 mg

1 h

Adults: 125 mg q treatment × 8 doses