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Table 4 Response of angiomyolipoma volume to everolimus by genotype

From: Renal phenotypes correlate with genotypes in unrelated individuals with tuberous sclerosis complex in China

 

TSC1

TSC2

P value

(n = 4)

(n = 68)

TSC1 versus TSC2

AML volume at baseline (mean ± SD, cm3)

70 ± 76

235 ± 538

0.54

Age range (years)

29–45

16–59

0.079

 Median age (years)

36

34

 

Sex

  

0.63

 Male

2

25

 

 Female

2

43

 

Familial/de novo

  

0.17

 Familial

2

12

 

 De novo

2

56

 

Everolimus (3 months)

   

 No. of response (%)

3 (75)

52 (76)

0.99

 % reduction from baseline value (mean ± SD, %)

39 ± 14

38 ± 17

0.89

Everolimus (6 months)

   

 No. of response (%)

4 (100)

56 (85)

0.99

 % reduction from baseline value (mean ± SD, %)

41 ± 15

43 ± 18

0.87

  1. AML angiomyolipomas