Table 4 Imaging assessments (amyloid load based on SAP scan)
Subject number | Amyloid type | SAP scan output | 1st value post diagnosis | Value at baseline* | Value at 1st follow-up | Value at 2nd follow-up | Value at 3rd follow-up | Value at 4th follow-up | Value at 5th follow-up | Value at 6th follow-up | Value at 7th follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|
Sustained responders | |||||||||||
012 | AA | Liver | Normal | Abnormal | – | – | – | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Adrenals | Abnormal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Overall | Moderate | Moderate | Moderate | – | – | – | – | – | – | ||
Δ from prior visit | – | Stable | Stable | – | – | – | – | – | – | ||
107 | AL | Liver | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | – | ||
Kidney | Obscured | Obscured | – | – | – | – | – | – | – | ||
Adrenals | Obscured | Obscured | – | – | – | – | – | – | – | ||
Overall | Large | Moderate | Moderate | Moderate | – | – | – | – | – | ||
Δ from prior visit | – | – | Better | Stable | – | – | – | – | – | ||
108 | AL | Liver | Abnormal | Abnormal | Abnormal | – | Abnormal | – | Normal | Normal | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | Normal | Normal | – | ||
Kidney | Abnormal | – | Abnormal | – | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | ||
Adrenals | Obscured | – | – | – | Abnormal | – | Normal | Normal | – | ||
Overall | Large | Moderate | Large | Moderate | Small | Small | Small | Small | Small | ||
Δ from prior visit | – | Better | Better | Stable | Better | Stable | Stable | – | Stable | ||
110 | AL | Liver | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | ||
Kidney | Obscured | Abnormal | Obscured | Obscured | Normal | Normal | – | – | – | ||
Adrenals | Obscured | Obscured | – | – | Normal | Normal | – | – | – | ||
Overall | Large | Large | Large | Large | Large | Large | – | – | – | ||
Δ from prior visit | – | – | Stable | Stable | Stable | Stable | – | – | – | ||
113 | AL | Liver | Abnormal | – | Abnormal | Abnormal | – | – | – | – | – |
Spleen | Abnormal | – | – | Abnormal | – | – | – | – | – | ||
Kidney | Obscured | – | Equivocal | Equivocal | – | – | – | – | – | ||
Adrenals | Obscured | – | – | Normal | – | – | – | – | – | ||
Overall | Large | Large | Small | Small | – | – | – | – | – | ||
Δ from prior visit | – | Better | – | – | – | – | – | – | – | ||
116 | AL | Liver | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | ||
Kidney | Obscured | Abnormal | Abnormal | – | Abnormal | Normal | Obscured | – | – | ||
Adrenals | Obscured | Abnormal | – | – | Obscured | Normal | – | – | – | ||
Overall | Large | Large | Moderate | Large | Moderate | Large | Large | – | – | ||
Δ from prior visit | – | Stable | Better | Better | Stable | Stable | Stable | – | – | ||
121 | AL | Liver | – | – | – | Normal | – | – | – | – | – |
Spleen | Abnormal | Abnormal | Equivocal | Equivocal | – | – | – | – | – | ||
Kidney | – | – | – | Normal | – | – | – | – | – | ||
Adrenals | – | – | – | Normal | – | – | – | – | – | ||
Overall | Large | Moderate | – | – | – | – | – | – | – | ||
Δ from prior visit | – | Better | Better | – | – | – | – | – | – | ||
Declining responders | |||||||||||
102 | AFib | Liver | Normal | – | – | – | Normal | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | ||
Adrenals | Obscured | – | – | – | Obscured | – | – | – | – | ||
Overall | Moderate | Small | Small | Small | Small | – | – | – | – | ||
Δ from prior visit | – | Stable | – | Stable | Stable | – | – | – | – | ||
104 | AFib | Liver | Normal | Normal | Normal | Normal | – | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | – | ||
Adrenals | Obscured | Obscured | Normal | Obscured | – | – | – | – | – | ||
Overall | Small | Small | Small | Moderate | – | – | – | – | – | ||
Δ from prior visit | – | – | Stable | Stable | – | – | – | – | – | ||
105 | AFib | Liver | Normal | – | – | – | – | – | – | – | – |
Spleen | Normal | Abnormal | – | – | – | – | – | – | – | ||
Kidney | Normal | Abnormal | – | – | – | – | – | – | – | ||
Adrenals | Normal | – | – | – | – | – | – | – | – | ||
Overall | None | Small | – | – | – | – | – | – | – | ||
Δ from prior visit | – | Stable | – | – | – | – | – | – | – | ||
106 | AFib | Liver | Normal | – | Normal | – | – | – | – | – | – |
Spleen | Abnormal | – | Abnormal | – | – | – | – | – | – | ||
Kidney | Equivocal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Adrenals | Normal | – | Normal | – | – | – | – | – | – | ||
Overall | Small | Moderate | Small | – | – | – | – | – | – | ||
Δ from prior visit | – | Stable | Stable | – | – | – | – | – | – | ||
109 | ApoA1 | Liver | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | ||
Kidney | Obscured | Obscured | – | – | Obscured | Not functioning | Abnormal | – | – | ||
Adrenals | Obscured | – | – | – | Obscured | Normal | – | – | – | ||
Overall | Large | Large | Large | Large | Large | Large | Large | – | – | ||
Δ from prior visit | – | Worse | – | Stable | Worse | Stable | – | – | – | ||
111 | AL | Liver | Abnormal | Abnormal | – | Abnormal | – | – | – | – | – |
Spleen | Abnormal | Abnormal | – | Abnormal | – | – | – | – | – | ||
Kidney | Obscured | Obscured | – | – | – | – | – | – | – | ||
Adrenals | Obscured | – | – | – | – | – | – | – | – | ||
Overall | Large | Large | Large | – | – | – | – | – | – | ||
Δ from prior visit | – | Stable | – | – | – | – | – | – | – | ||
114 | AL | Liver | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | ||
Adrenals | Obscured | – | – | – | – | – | – | – | – | ||
Overall | Large | Moderate | – | Moderate | Moderate | Large | – | – | – | ||
Δ from prior visit | – | Better | Better | Worse | Stable | Better | – | – | – | ||
115 | AL | Liver | Normal | Abnormal | – | Abnormal | Abnormal | Abnormal | – | – | – |
Spleen | Abnormal | Abnormal | – | Abnormal | Abnormal | Abnormal | – | – | – | ||
Kidney | Obscured | – | – | – | Obscured | Obscured | – | – | – | ||
Adrenals | Obscured | – | – | – | Obscured | Obscured | – | – | – | ||
Overall | Large | – | – | Large | Large | Large | – | – | – | ||
Δ from prior visit | – | Stable | Stable | Stable | – | Better | – | – | – | ||
117 | AFib | Liver | – | – | – | – | – | – | – | – | – |
Spleen | Abnormal† | Abnormal† | Abnormal | Abnormal | – | – | – | – | – | ||
Kidney | Abnormal† | Abnormal† | Abnormal | Abnormal | – | – | – | – | – | ||
Adrenals | – | – | – | – | – | – | – | – | – | ||
Overall | Small† | Small† | Small | Small | – | – | – | – | – | ||
Δ from prior visit | – | – | Stable | – | – | – | – | – | – | ||
118 | AL | Liver | – | – | Normal | Normal | Normal | – | – | – | – |
Spleen | – | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | ||
Kidney | – | – | Normal | Normal | Normal | – | – | – | – | ||
Adrenals | – | – | Normal | Normal | Normal | – | – | – | – | ||
Overall | Moderate | Small | Small | Small | Small | – | – | – | – | ||
Δ from prior visit | – | Stable | Stable | Stable | Stable | – | – | – | – | ||
Non-responder | |||||||||||
119 | AL | Liver | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | – | Abnormal | – | – | – | – | ||
Adrenals | Obscured | – | – | – | – | – | – | – | – | ||
Overall | Large | Large | Large | Large | Large | – | – | – | – | ||
Δ from prior visit | – | Stable | Stable | Stable | – | – | – | – | – | ||
120 | AL | Liver | Normal | – | – | – | – | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Adrenals | Abnormal | Abnormal | Abnormal | – | – | – | – | – | – | ||
Overall | Moderate | Moderate | Moderate | – | – | – | – | – | – | ||
Δ from prior visit | – | – | Better | – | – | – | – | – | – | ||
Non-therapeutic dose in FIHS | |||||||||||
001 | AA | Liver | Normal | Normal | – | – | – | – | – | – | – |
Spleen | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | ||
Kidney | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | Abnormal | – | – | – | ||
Adrenals | Obscured | Obscured | – | – | – | – | – | – | – | ||
Overall | Moderate | Moderate | Small | – | – | Small | – | – | – | ||
Δ from prior visit | – | – | Better | – | Stable | Better | – | – | – | ||