Table 1 Clinical features of patients reported with VCP disease and malignancies
From: A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy
Case | Cancer Type | Current Age y (Age deceased) | Sex | VCP variant (c.DNA;protein) | Myopathy/Age of onset y | PDB/Age of onset y | FTD/Age of onset y | Cancer age of onset y | Rate in VCP disease | Incidence in general population |
|---|---|---|---|---|---|---|---|---|---|---|
1 | Peripheral nerve sheath tumor | 56 | M | c.464G > A; p.R155H |  + /36 |  + /33 | – | 45 | 1/231 | 1/100000[30] |
2 | Pleomorphic xanthoastrocytoma | (35) | M | c.572G > A; p.R191Q | – | – | – | 32 | 1/231 |  < 1/285714[31] |
3 | Thymoma | (48) | F | c.463C > T; p.R155C |  + /45 | – | – | 30 | 1/231 | 1/769231[32] |
4 | Breast invasive ductal carcinoma | 76 | F | c.476G > A; p.R159H | – | – |  + /71 | 35 | 1/231 | 1/8 [33] |
5 | Pancreatic ductal adenocarcinoma | (55) | M | c.463C > T; p.R155C |  + /50 |  + /40 | – | 54 | 1/231 | 1/7576[34] |
6 | Endometrial adenocarcinoma | (60) | F | c.463C > T; p.R155C |  + /34 |  + / 45 |  + /59 | 55 | 1/231 | 1/6667[35] |
7 | Prostate adenocarcinoma | 72 | M | c.464G > A; p.R155H |  + /33 | - | – | 69 | 1/231 | 1/14[36] |