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Table 1 Demographical characteristics

From: Patient-reported outcomes in a Chinese cohort of osteogenesis imperfecta unveil psycho-physical stratifications associated with clinical manifestations

 

Child group (< 18 years)

Adult group (≥ 18 years)

P value*

Numbers of patients

74

16

 

Age (years)

10.7 (IQR 7.5 ~ 14)

26.7 (IQR 19 ~ 31)

 

Male %

60.8% (45 out of 74)

62.5% (10 out of 16)

1.0

Sillence subtypes

  

0.015

 I

n = 7a (11.1%) b

n = 1 (6.7%)

 

 III

n = 8 (12.7%)

n = 7 (46.7%)

 

 IV

n = 40 (63.5%)

n = 6 (40%)

 

 V

n = 8 (12.7%)

n = 1 (6.7%)

 

Number of fractures per year

1.1 (IQR 0.6 ~ 1.4)

0.5 (IQR 0.2 ~ 0.5)

0.003

Leg length discrepancy (LLD)

61.8% (42 out of 68)

92.8% (13 out of 14)

0.052

Dentinogenesis imperfecta

58.4% (38 out of 65)

50% (7 out of 14)

0.78

Limited joint mobility

22.4% (15 out of 67)

42.8% (6 out of 14)

0.21

Hearing loss

5.9% (4 out of 68)

7.1% (1 out of 14)

1.0

Scoliosis

47.8% (32 out of 67)

73.3% (11 out of 15)

0.13

Radial head dislocation

18.2 (12 out of 66)

28.6% (4 out of 14)

0.61

Sclera

73.1% (49 out of 67)

71.4% (10 out of 14)

1.0

Muscle strengthsc

4.0 (IQR 3.7 ~ 4.3)

3.6 (IQR 3.3 ~ 4.0)

0.19

 2

n = 3a

n = 0

 

 2+

n = 1

n = 0

 

 3

n = 6

n = 1

 

 3+

n = 7

n = 1

 

 4−

n = 1

n = 0

 

 4

n = 19

n = 2

 

 4+

n = 4

n = 2

 

 5

n = 2

n = 1

 
  1. *Based on Pearson χ2 testing (for categorical variables) or Wilcoxon rank-sum testing (for continuous variables). IQR inter-quartile range
  2. an is the number of patients
  3. bOut of patients of whom Sillence type information was available
  4. c3+ is better than 3 but poorer than 4 and 4-
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172