Table 1 Modified Fabry- specific risk stratification for severe COVID-19 originally suggested by the international expert recommendations [11]

Patients with uncomplicated FD

No existing severe organ damage at heart, lungs, kidney, and CNS

A

Patients with advanced FD

Patients carrying at least one of the following:

I. CKD (defined as pathological albuminuria > 30 mg/g urinary creatinine or eGFR < 60 mL/min/1.73m2)

II. Heart involvement: arrhythmia or severe LVH or cardiomegaly

III. CNS involvement: Stroke or TIA or WML

IV. Pulmonary involvement: FEV1 decrease

V. Age older than 40 years for classic males or older than 55 years for all other disease types

B

Patients with transplantation

C