Fig. 4

MANF is marginally elevated in individuals with RYR1 mutations. A Extracellular human MANF in plasma obtained from healthy volunteers or individuals with RYR1 mutations, mean ± SEM, n = 7 healthy volunteers, n = 9 RYR1 mutations, participant sex indicated next to confirmed genotype, p = 0.1665, two-tailed t-test. B, C Circulating levels of MANF is significantly correlated with age in individuals with RYR1 mutations, but not healthy volunteers, n = 7 healthy volunteers, r = -0.5122, p = 0.2398; n = 9 RYR1 mutations, r = 0.7511 *p = 0.0196