Fig. 3

Regional distribution of phenotype at enrollment in symptomatic patients. The proportion of patients with each phenotype shown by region in a the overall population of symptomatic patients and by genotype category, b ATTRwt amyloidosis, c Val30Met early onset, d Val30Met late onset, e cardiac mutations, and f non-Val30Met excluding cardiac mutations. The sum of values for each region in each figure equals one. Val30Met early onset and late onset n based on all patients with available data for disease diagnosis; 128 patients with the Val30Met mutation and no date of disease diagnosis were not included in the genotype category breakdown. Cardiac mutations include Val122Ile, Leu111Met, Thr60Ala, and Ile68Leu. ATTRwt amyloidosis = wild-type transthyretin amyloidosis