Table 1 Patient characteristics
Items | FAS (n = 17) | |
|---|---|---|
Age (years) | Mean ± SD | 33.6 ± 8.0 |
Sex | Male/female | 16 (94.1%)/1 (5.9%) |
Diseases | Duchenne muscular dystrophy | 13 (76.5%) |
Becker muscular dystrophy | 3 (17.6%) | |
Limb-Girdle muscular dystrophy | 1 (5.9%) | |
Previous illness | No/Yes | 11 (64.7%)/6 (35.3%) |
Severe heart failure | 3 (17.6%) | |
Lethal arrhythmia | 2 (11.8%) | |
acute nephritis/severe renal dysfunction | 1 (5.9%) | |
Thrombosis/embolism | 1 (5.9%) | |
Complications | No/yes | 12 (70.6%)/5 (29.4%) |
Biliary disorders (gall stone, cholecystolithiasis) | 1 (5.9%) | |
Rash | 2 (11.8%) | |
Others | 2 (11.8%) | |
Allergy | No/yes | 9 (52.9%)/8 (47.1%) |
Rhinitis | 3 (17.6%) | |
Hay fever | 2 (11.8%) | |
Atopic dermatitis | 3 (17.6%) | |
Drug hypersensitivity (Not for tranilast) | 2 (11.8%) | |
Mitral regurgitation | Absent or trivial/mild/moderate | 7 (41.2%)/7 (41.2%)/3 (17.6%) |
BNP (pg/mL) | GM ± GSD IQR | 192.9 ± 1.72 (132–260) |
hANP (pg/mL) | GM ± GSD IQR | 189.7 ± 1.74 (152–284) |
cTnT (ng/mL) | GM ± GSD IQR | 0.026 ± 1.76 (0.02–0.03) |
FS (%) | Mean ± SD IQR | 9.0 ± 3.8 (6–13) |
LVDD (mm) | Mean ± SD IQR | 58.1 ± 6.3 (55–61) |
Motor function | Ambulant/non-ambulant | 1 (5.9%)/ 16 (94.1%) |
Mechanical ventilation | No/intermittent/full-time | 2 (11.8%)/13 (76.5%)/ 2 (11.8%) |
Oxygen inhalation | No/yes | 16 (94.1%)/1 (5.9%) |
Nutrition | Oral/tube feeding | 8 (47.1%)/9 (52.9%) |
ACEI/ARB | Yes/no | 15 (88.2%)/2 (11.8%) |
Beta-blocker | Yes/no | 15 (88.2%)/2 (11.8%) |
Digitalis | Yes/no | 2 (11.8%)/15 (88.2%) |
Diuretics (except aldosterone receptor antagonist) | Yes/no | 6 (35.3%)/11 (64.7%) |
Aldosterone receptor antagonist | Yes/no | 8 (47.1%)/9 (52.9%) |
Cardiotonic agents | Yes/no | 3 (17.6%)/14 (82.4%) |
Anti-arrhythmic agents | Yes/no | 10 (58.8%)/7 (41.2%) |