Fig. 3
From: Application of Bayesian methods to accelerate rare disease drug development: scopes and hurdles
Top panel: shows a 2 × 2 crossover design where a group of participants are randomized to a sequence of treatments to first receive treatment A then B or first receive B then A. Bottom panel: shows a small n, sequential, multiple assignment, randomized trial design with three treatment options like the ARAMIS design. R denotes randomization and A, B, C denote intervention options