The national economic burden of rare disease in the United States in 2019

Table 1 Rare disease prevalence for 379 RDs included in the study by age and insurance coverage, in 2019

	No. of persons estimated to have RD	Population	Prevalence (%)
Age
< 18	1,322,886	71,580,109	1.8
18–64	8,371,639	182,528,781	4.6
≥ 65	5,850,660	51,822,242	11.3
Insurance
Commercial	7,124,610	188,738,510	3.8
Medicaid	1,582,062	57,833,466	2.7
Medicare	6,838,513	59,359,156	11.5
Total	15,545,185	305,931,132	5.1

Source: Analyses of 2018 de-identified Normative Health Information(dNHI) claims, a large claims database for the privately insured, 2019 Medicare claims, 2016 Medicaid claims, and Census population projection for 2019 (the latest available at the time of this study)

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