Table 1 Overview of patients with Pompe disease with a proven SARS-CoV-2 infection
Patient; Pompe type | Age | Gender | Age at diagnosis | Age at start ERT | Pompe disease severity | Recent immune modulation | BMI | FVC sitting/supine before infection | FVC reduction after infection | COVID disease duration (days) | Symptoms | Long-term symtoms | Chest X-ray | SARS-CoV-2 antibody titer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. Classic infantile | 8 | F | 4 months | 4 months | Moderate. Responsive to ERT | No | 20.7 | 67/no recent measurement | No | 7 | Cough, headache | No | n/a | n/a |
2. Classic infantile | 8 | F | 8 days | 10 days | Moderate. Responsive to ERT | No | 17.6 | 91/74 | n/a | 3 | Fever, headache, ear pain | No | n/a | n/a |
3. Classic infantile | 11 | F | 3 days | 8 days | Moderate. Responsive to ERT | No | 20.3 | 86/87 | n/a | 2 | Tiredness, sore throat | No | n/a | n/a |
4. Classic infantile | 16 | F | 6 days | 16 days | Moderate. Wheelchair bound | No | 22.3 | 56/no recent measurement | Yes; normalized after 1 month | 7 | Cough, stuffed nose, left-sided muscle weakness | Left-sided muscle weakness | n/a | n/a |
5. Childhood | 20 | M | 2 years; 4 months | 9 years; 9 months | Mild | No | 19.9 | 94/90 | No | 15 | Sore throat, stuffed nose, general weakness, anosmia, loss of taste | No | n/a | n/a |
6. Classic infantile | 22 | F | 12 years; 3 months | No ERT | Mild | No | 21.5 | 90/86 | n/a | 8 | Fever, cough, anosmia, headache, stuffed nose | No | n/a | n/a |
7. Classic infantile | 22 | M | 20 days | 4 months | Severe. Non-invasive ventilation, wheelchair bound | No | 24.6 | 27/not possible | No | n/a | No symptoms | No | n/a | n/a |
8. Childhood | 22 | M | 3 years; 6 months | 6 years | Mild | No | 25.1 | 79/68 | No | 6 | Cough, anosmia | Anosmia | n/a | n/a |
9. Childhooda | 29 | F | 15 years | 23 years | Mild | No | 30 | 125/115 | No | 10 | Cough, stuffed nose, myalgia, headache, fatigue | Fatigue | Normal after recovery | n/a |
10. Childhood | 29 | M | 2 years | 15 years | Mild | No | 23 | 102/94 | No | 16 | Cough, stuffed nose, anosmia, loss of taste | Anosmia | n/a | Positive 1,7 months after first symptoms |
11. Late onset | 40 | F | 24 years | 26 years | Moderate. Use of nightly non-invasive ventilation | No | 26 | 50/25 | No | 14 | Fever, dyspnea, fatigue, myalgia, nausea, chest pain, anosmia, loss of taste | Fatigue, anosmia, chest pains, pain between shoulders, palpitations | n/a | Positive 4 months after first symptoms |
12. Late onset | 49 | F | 37 years | 38 years | Mild | No | 27 | 61/34 | No | 19 | Cough, myalgia, fever, chest pain, sore throat, headache, diarrhoea | Fever, dyspnea during exercise, heart palpitations | Normal after recovery | n/a |
13. Late onset | 49 | F | 36 years | 38 years | Moderate. Use of walking aid | No | 27.9 | 82/50 | Yes, asymptomatic, no new spirometry yet | 7 | Myalgia, nausea, bloated feeling | No | n/a | n/a |
14. Late onset | 60 | M | 56 years | Discontinued in 2018 | Mild | No | 27 | 83/78 | No | 9 | Cough, fever, headache | No | n/a | n/a |
15. Late onseta | 62 | F | 59 years | 59 years | Mild | No | 28.1 | 82/64 | No | n/a | No symptoms | No | n/a | n/a |