Fig. 1
Distribution of kidney parameters within patient cohorts. Filled circles represent values of eGFR (A) and left kidney volume (RV/BSA) (B) for individual patients as determined by methods adjusted for children [20, 21]. Median values of cohorts, values for normal kidney function (estimated glomerular filtration rate (eGFR) > 90 ml/min/1.73 m2) and normal range of body-surface-area related renal volume (RV/BSA, 36–94 ml/m2) [21] are indicated. When disregarding two ARPKD patients with normal kidney function as statistical outliers, eGFR values are normally distributed and eGFR significantly differ between cohorts, (p < 0.05, ANOVA, Tukey’s). Kidney volumes of ARPKD patients show a wide distribution, with similar size of left and right organs, (B) and Additional file 1: Fig. S1, and differ from those determined for NPH and BBS patients (p < 0.05, Kruskal–Wallis, Dunn’s). Size of right kidneys and total kidney volumes are provided in Additional file 1: Fig. S1