Table 3 Human Leucocyte Antigen (HLA) alleles in patients with RP with and without GD
From: Co-occurrence of relapsing polychondritis and autoimmune thyroid diseases
Patients with GD (N = 5) | Patients without GD (N = 88) | P-value* | Odds ratio [95% confidence interval] | |
|---|---|---|---|---|
HLA-A | ||||
02:01 | 2 (20%) | 19 (10.8%) | 0.31 | 2.01 [0.29–9.78] |
02:06 | 1 (10%) | 19 (10.8%) | 1.00 | 0.92 [0.040–6.46] |
02:07** | 1 (10%) | 4 (2.3%) | 0.24 | 4.70 [0.18–40.87] |
11:01 | 1 (10%) | 27 (15.3%) | 1.00 | 0.61 [0.027–4.12] |
24:02 | 3 (30%) | 55 (31.3%) | 1.00 | 0.94 [0.20–3.67] |
26:01 | 0 (0%) | 12 (6.8%) | 1.00 | 0 [0.00–6.01] |
26:03 | 1 (10%) | 4 (2.3%) | 0.24 | 4.70 [0.18–40.87] |
31:01 | 2 (20%) | 19 (10.8%) | 0.31 | 2.06 [0.29–9.78] |
33:03 | 0 (0%) | 14 (8.0%) | 1.00 | 0 [0.00–5.97] |
HLA-B | ||||
07:02 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
15:01 | 2 (20%) | 18 (10.2%) | 0.30 | 2.18 [0.31–10.48] |
35:01* | 1 (10%) | 18 (10.2%) | 1.00 | 0.98 [0.043–6.93] |
39:01 | 0 (0%) | 7 (4.0%) | 1.00 | 0 [0.00–11.88] |
40:01 | 0 (0%) | 11 (6.3%) | 1.00 | 0 [0.00–6.51] |
40:02 | 1 (10%) | 12 (6.8%) | 0.52 | 1.51 [0.065–11.84] |
40:06 | 0 (0%) | 4 (2.3%) | 1.00 | 0 [0.00–21.06] |
44:03 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
46:01* | 1 (10%) | 4 (2.3%) | 0.24 | 4.70 [0.18–40.87] |
48:01 | 0 (0%) | 4 (2.3%) | 1.00 | 0 [0.00–21.06] |
51:01† | 2 (20%) | 14 (8.0%) | 0.21 | 2.87 [0.40–14.55] |
52:01 | 1 (10%) | 16 (9.1%) | 1.00 | 1.11 [0.049–8.07] |
54:01 | 1 (10%) | 18 (10.2%) | 1.00 | 1.00 [0.043–6.93] |
55:02 | 0 (0%) | 6 (3.4%) | 1.00 | 0.98 [0.00–15.36] |
59:01 | 0/10 (0%) | 5/176 (2.8%) | 1.00 | 0 [0.00–17.83] |
67:01*** | 1/10 (10%) | 5/176 (2.8%) | 0.29 | 3.75 [0.15–36.33] |
HLA-Cw | ||||
01:02 | 2 (20%) | 33 (18.8%) | 1.00 | 1.08 [0.16–5.03] |
03:03 | 3 (30%) | 26 (14.8%) | 0.19 | 2.46 [0.52–9.91] |
03:04 | 1 (10%) | 22 (12.5%) | 1.00 | 0.78 [0.035–5.36] |
04:01 | 0 (10%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
07:02 | 1 (10%) | 28 (15.9%) | 1.00 | 0.59 [0.026–3.94] |
08:01 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
12:02 | 1 (10%) | 17 (9.7%) | 1.00 | 1.04 [0.046–7.46] |
14:02 | 2 (20%) | 11 (6.3%) | 0.15 | 3.71 [0.51–20.24] |
14:03 | 0 (0%) | 10 (5.7%) | 1.00 | 0 [0.00–7.14] |
15:02 | 0 (0%) | 4 (2.3%) | 1.00 | 0 [0.00–21.06] |
HLA-DRB1 | ||||
01:01 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
04:03 | 0 (0%) | 6 (3.4%) | 1.00 | 0 [0.00–15.36] |
04:05 | 0 (0%) | 31 (17.6%) | 0.22 | 0 [0.0–2.14] |
04:06 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
04:07 | 1 (10%) | 2 (1.1%) | 0.15 | 9.38 [0.30–129.97] |
04:10 | 0 (0%) | 3 (1.7%) | 1.00 | 0 [0.00–32.00] |
08:02 | 1 (10%) | 7 (4.0%) | 0.36 | 2.66 [0.11–20.53] |
08:03 | 0 (0%) | 11 (6.3%) | 1.00 | 0 [0.00–6.51] |
09:01 | 2 (20%) | 22 (12.5%) | 0.62 | 1.74 [0.25–8.14] |
11:01 | 0 (0%) | 5 (2.8%) | 1.00 | 0 [0.00–17.83] |
12:01 | 2 (20%) | 6 (3.4%) | 0.061 | 6.92 [0.89–38.52] |
13:02 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
14:03* | 0 (0%) | 2 (1.1%) | 1.00 | 0 [0.00–63.42] |
14:05 | 1 (10%) | 0 (0%) | 0.054 | Inf [0.93–Inf] |
14:54 | 1 (10%) | 8 (4.5%) | 0.40 | 2.32 [0.096–18.37] |
15:01 | 1 (10%) | 15 (8.5%) | 0.60 | 1.19 [0.052–8.78] |
15:02 | 0 (0%) | 16 (9.1%) | 1.00 | 0 [0.00–5.00] |
16:02*** | 1 (10%) | 5 (2.8%) | 0.29 | 3.75 [0.15–36.33] |
HLA-DQB1 | ||||
03:01 | 2 (20%) | 16 (9.1%) | 0.25 | 2.48 [0.35–12.21] |
03:02 | 1 (10%) | 23 (13.1%) | 1.00 | 0.74 [0.033–5.06] |
03:03 | 3 (30%) | 26 (14.8%) | 0.19 | 2.46 [0.52–9.91] |
04:01 | 0 (0%) | 31 (17.6%) | 0.22 | 0 [0.00–2.14] |
04:02 | 1 (10%) | 5 (2.8%) | 0.29 | 3.75 [0.15–36.33] |
05:01 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
05:02*** | 1 (10%) | 12 (6.8%) | 0.52 | 1.51 [0.065–11.85] |
05:03 | 1 (10%) | 1 (0.057%) | 0.10 | 18.49 [0.46–751.60] |
06:01 | 0 (0%) | 27 (15.3%) | 0.36 | 0 [0.00–2.56] |
06:02 | 1 (10%) | 15 (8.5%) | 0.60 | 1.19 [0.052–8.78] |
06:04 | 0 (0%) | 8 (4.5%) | 1.00 | 0 [0.00–9.71] |
HLA-DPB1 | ||||
02:01 | 1 (10%) | 46 (26.1%) | 0.46 | 0.32 [0.014–2.07] |
02:02 | 2 (20%) | 4 (2.3%) | 0.035 | 10.41 [1.23–65.38] |
03:01 | 0 (0%) | 5 (2.8%) | 1.00 | 0 [0.00–17.83] |
04:01 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
04:02 | 0 (0%) | 9 (5.1%) | 1.00 | 0 [0.00–8.21] |
05:01* | 5 (50%) | 83 (47.2%) | 1.00 | 1.12 [0.31–4.05] |
09:01 | 1 (10%) | 11 (6.3%) | 0.50 | 1.66 [0.071–13.38] |
13:01 | 1 (10%) | 3 (1.7%) | 0.20 | 6.27 [0.22–63.23] |