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Table 5 Bootstrapping method descriptive results of the 500 resamples for the different biochemical models assessed

From: Biochemical algorithm to identify individuals with ALPL variants among subjects with persistent hypophosphatasaemia

 

Variables included

AUC ROC curve

Model 1

ALP < 25

0.68 (0.63–0.72)

Model 2

ALP < 25 + PEA > 30

0.87 (0.82–0.9)

Model 3

ALP < 25 + PLP > 180

0.87 (0.82–0.91)

Model 4

ALP < 25 + PLP > 180 + PEA > 30

0.94 (0.91–0.97)

  1. ALP alkaline phosphatase (IU/L), PLP serum pyridoxal-5′-phosphate (nmol/L), PEA urinary phosphoetanolamine (µmol/g creatinine), AUC area under the curve, ROC curve receiver operating characteristic curve
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172