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Table 2 Evolution of serum alkaline phosphatase, serum piridoxal-5-phosphate and urinary phosphoetanolamine levels in both groups

From: Biochemical algorithm to identify individuals with ALPL variants among subjects with persistent hypophosphatasaemia

 

Baseline

6 months

1 year

18 months

2 years

−GT

+GT

−GT

+GT

−GT

+GT

−GT

+GT

−GT

+GT

ALP, IU/L

31 (27–36)

26 (22–30)*

30 (26–35.8)

25 (20.5–27.5*

30.5 (26–37)

24.5 (21–29)*

31 (27–40)

25 (21.8–29)*

33 (27–40)

26 (20.75–30.25)*

PLP (nmol/L)

79.49 (57.7–124.4)

200 (132.75–270.9)*

  

99.54 (52.2–141.92)

345.35 (242.67–573.28)*

  

82.26 (56.18–143.49)

293.9 (207.5–479.2)*

PEA µmol/g. creatinine

13.5 (8.25–26.5)

40.5 (18.5–67.8)*

  

16 (11–22)

41.5 (25.5–75.5)*

  

18 (12.5–24)

22 (16–44)*

  1. Data are expressed as median (interquartile range); *p value < 0.001 in the comparison of biochemical parameters between the +GT and −GT groups during the visits assessed
  2. +GT positive genetic test, −GT negative genetic test, Bsl baseline, m months, y years, ALP alkaline phosphatase