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Table 3 Spearman correlation between ACC metrics parameters and Cochet-Bonnet esthesiometry

From: Eight months follow-up of corneal nerves and sensitivity after treatment with cenegermin for neurotrophic keratopathy

 

CNFL/CBE

CTBD/CBE

CNFraD/CBE

C

I

N

S

T

C

I

N

S

T

C

I

N

S

T

0wk

–

0,61*

0.16

0.49τ

0.82*

–

–

–

0.49τ

0.59*

–

–

–

0.72*

0.62*

8wk

0.76*

0.82*

0.59*

0.75*

0.87*

0.43τ

0.67*

0.57*

0.76*

0.87*

0.43τ

0.82*

0.65*

0.77*

0.86*

2mth (fu)

0.62*

0.75*

0.68*

0.87*

0.87*

0.62*

0.64*

0.67*

0.80*

0.89*

0.62*

0.76*

0.75*

0.76*

0.77*

4mth (fu)

0.75*

0.69*

0.73*

0.88*

0.79*

0.73*

0.72*

0.89*

0.89*

0.71*

0.77*

0.67*

0.79*

0.77*

0.63*

8mth (fu)

0.79*

0.92*

0.87*

0.88*

0.68*

0.79*

0.89*

0.78*

0.82*

0.63*

0.79*

0.94*

0.83*

0.90*

0.71*

  1. A strong correlation between sensitivity and IVCM parameters was found for all sectors from the 2-month follow up onward
  2. C, central sector; CBE, Cochet-Bonnet esthesiometry; CNFL, corneal nerve fiber length; CNFraD, corneal nerve fiber fractal dimension; CTBD, corneal nerve fiber total branch density; I, inferior sector; N, nasal sector; S, superior sector; T, temporal sector; 0 wk, baseline (start of treatment); 8 wk, 8 weeks (end of treatment); 2 mth (fu), 2-month follow-up; 4 mth (fu), 4-month follow-up; 8 mth (fu), 8-month follow-up
  3. (τ) value with statistical significance at threshold 0.05 (one-tailed)
  4. (*) value with statistical significance at threshold 0.01 (one-tailed)
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172