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Table 3 PedsQL summary (age 13–17 years; adolescent reported)

From: Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency

 

Patient 10a

Patient 11a

Patient 12a

Patient 13a

Mean (SD)

PedsQL total score at baseline

23.9

85.9

84.8

58.7

63.3 (29.1)

Change in PedsQL total score at Week 52

21.7

 − 14.1

9.8

5.8 (18.3)

Percent change in PedsQL total score at Week 52

90.9

 − 16.5

11.5

 

28.7 (55.7)

P = 0.0106

PF

21.9

 − 18.8

15.6

6.3 (21.9)

PH

21.7

 − 11.7

6.7

5.6 (16.7)

Body weight, percent change

 − 26.2

 − 30.2

 − 35.6

 − 27.3

 − 29.8 (4.2)

Most hunger, percent change

 − 54.7

 − 37.5

 − 1.4

 − 3.5

 − 24.3 (26.2)

  1. PedsQL, Pediatric Quality of Life Inventory; PH, psychosocial health; PF, physical functioning; POMC, proopiomelanocortin; SD, standard deviation
  2. aPatient enrolled in POMC trial