Fig. 3
From: Adult-onset CblC deficiency: a challenging diagnosis involving different adult clinical specialists
Renal biopsy. Optical microscopy (a, b) and electron microscopy (c–e) of the reported case of adult-onset CblC disease. a The glomerular basement membranes are diffusely slightly thickened and show extensive double contours or collapse (PAS, original magnification × 400). b pseudothrombi are occasionally observed in glomerular capillary lumens (AFOG, original magnification × 400). c the glomerulus shows extensive duplication of basement membranes (“multilayering” aspect) associated with subendothelial expansion, endothelial swelling and loss of normal fenestration (chronic microangiopathic damage; original magnification × 5200). d, e Electron dense deposits with a vaguely structured annular or microtubular appearance are evident in the basement membranes (mainly subendothelial and intramembranous) and in the mesangium (original magnification × 15,500 in d and e)