Table 3 Parameter estimates for longitudinal models of height, weight and BMI SD by GC groups
From: Growth pattern trajectories in boys with Duchenne muscular dystrophy
Height | Weight | BMI | |
|---|---|---|---|
Est mean SD at age 5 years | Est mean SD at age 5 years | Est mean SD at age 5 years | |
Naive | − 0.84 (− 1.19, − 0.48) | − 0.2 (− 0.63,0.23) | 0.64 (0.23,1.06) |
Daily deflazacort (DD) | − 0.91 (− 1.13,− 0.68) | 0.14 (− 0.14,0.42) | 1.18 (0.92,1.44) |
Intermittent deflazacort (ID) | − 0.69 (− 1.06, − 0.33) | 0.2 (− 0.25,0.65) | 0.92 (0.5,1.34) |
Daily prednisolone (DP) | − 0.94 (− 1.12, − 0.77) | − 0.36 (− 0.57,− 0.15) | 0.59 (0.39,0.79) |
Intermittent prednisolone (IP) | − 1.21 (− 1.41, − 1.02) | − 0.59 (− 0.82,− 0.35) | 0.42 (0.2,0.64) |
All patients | − 0.96 (− 1.06, − 0.86) | − 0.27 (− 0.4,− 0.14) | 0.68 (0.56,0.79) |
Est change in SD per year (95% CI) | Est change in SD per year (95% CI) | Est change in SD per year (95% CI) | |
|---|---|---|---|
Naive | 0.03 (− 0.07, 0.13) | 0.09 (− 0.05,0.23) | 0.02 (− 0.11,0.16) |
Daily deflazacort (DD) | − 0.25 (− 0.30, − 0.21) | 0.1 (0.04,0.16) | 0.2 (0.14, 0.26) |
Intermittent deflazacort (ID) | − 0.06 (− 0.14, 0.02) | − 0.03 (− 0.13,0.07) | − 0.02 (− 0.12, 0.09) |
Daily prednisolone (DP) | − 0.16 (− 0.19, − 0.12) | 0.17 (0.12,0.21) | 0.22 (0.18, 0.27) |
Intermittent prednisolone (IP) | 0.12 (0.08, 0.15) | 0.25 (0.2,0.29) | 0.17 (0.12, 0.22) |
All patients | − 0.08 (− 0.1, − 0.06) | 0.16 (0.13,0.19) | 0.18 (0.15, 0.2) |
Daily versus intermittent | |||
Difference in SDS at age 5 years (I-D) | − 0.16 (− 0.38,0.06) P = 0.16 | − 0.24 (− 0.51,0.03) P = 0.09 | − 0.28 (− 0.54, − 0.03) P = 0.03 |
Difference in annual change (I-D) | 0.27 (0.22, 0.31) P < 0.01 | 0.05 (− 0.01,0.11) P = 0.09 | − 0.08 (− 0.14, − 0.02) P < 0.01 |
Deflazacort versus prednisolone | |||
Difference in SDS at age 5 years (P-D) | − 0.2 (− 0.43,0.04) P = 0.10 | − 0.61 (− 0.89, − 0.32) P < 0.01 | − 0.59 (− 0.86, − 0.32) P < 0.01 |
Difference in annual change (P-D) | 0.16 (0.11, 0.22) P < 0.01 | 0.13 (0.07, 0.19) P < 0.01 | 0.05 (− 0.01, 0.12) P = 0.07 |
Age at starting GCs | |||
Change in SDS at age 5 years per year later GCs initiated | − 0.1 (− 0.17, − 0.02) P = 0.01 | − 0.27 (− 0.36, − 0.18) P < 0.01 | − 0.27 (− 0.36, − 0.18) P < 0.01 |
Annual change in SDS per year later GCs initiated | 0.01 (0, 0.03) P = 0.07 | 0.03 (0.01, 0.04) P < 0.01 | 0.03 (0.01, 0.05) P = 0.01 |