Table 2 Clinical outcomes from patients with severe haemophilia B on FIX prophylaxis in CHESS II (past 12 months)
Clinical outcomes | SHL patients (n = 42) | EHL patients (n = 33) | All patients (n = 75) |
|---|---|---|---|
ABR, mean (SD)† | 2.4 (1.67) | 2.5 (2.62) | 2.4 (2.14) |
Number of bleeds per year, n (%) | |||
None | 6 (15) | 5 (15) | 11 (15) |
1 | 6 (15) | 5 (15) | 11 (15) |
≥ 2 | 28 (70) | 23 (70) | 51 (70) |
History of joint surgery, n (%)‡ | 10 (24) | 11 (33) | 21 (28) |
Bleed-related hospitalisations, mean (SD)# | 0.76 (0.95) | 0.55 (1.30) | 0.67 (1.10) |
Bleed-related hospital days per patient, mean (SD) | 1.2 (2.9) | 1.9 (5.2) | 1.5 (4.1) |
Target joints, mean (SD) | 0.3 (0.71) | 0.4 (0.79) | 0.4 (0.74) |
Number of target joints, n (%) | 35 (83) | 23 (70) | 58 (77) |
None | 3 (7) | 8 (24) | 11 (15) |
1 | 4 (10) | 2 (6) | 6 (8) |
≥ 2 | |||
Problem joints, mean (SD) | 0.6 (0.94) | 0.9 (1.32) | 0.7 (1.12) |
Number of problem joints, n (%) | |||
None | 26 (62) | 19 (58) | 45 (60) |
1 | 8 (19) | 6 (18) | 14 (19) |
≥ 2 | 8 (19) | 8 (24) | 16 (21) |