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Table 2 Clinical outcomes from patients with severe haemophilia B on FIX prophylaxis in CHESS II (past 12 months)

From: Clinical, humanistic, and economic burden of severe haemophilia B in adults receiving factor IX prophylaxis: findings from the CHESS II real-world burden of illness study in Europe

Clinical outcomes SHL patients
(n = 42)
EHL patients
(n = 33)
All patients
(n = 75)
ABR, mean (SD) 2.4 (1.67) 2.5 (2.62) 2.4 (2.14)
Number of bleeds per year, n (%)    
 None 6 (15) 5 (15) 11 (15)
 1 6 (15) 5 (15) 11 (15)
 ≥ 2 28 (70) 23 (70) 51 (70)
History of joint surgery, n (%) 10 (24) 11 (33) 21 (28)
Bleed-related hospitalisations, mean (SD)# 0.76 (0.95) 0.55 (1.30) 0.67 (1.10)
Bleed-related hospital days per patient, mean (SD) 1.2 (2.9) 1.9 (5.2) 1.5 (4.1)
Target joints, mean (SD) 0.3 (0.71) 0.4 (0.79) 0.4 (0.74)
Number of target joints, n (%) 35 (83) 23 (70) 58 (77)
None 3 (7) 8 (24) 11 (15)
 1 4 (10) 2 (6) 6 (8)
 ≥ 2    
Problem joints, mean (SD) 0.6 (0.94) 0.9 (1.32) 0.7 (1.12)
Number of problem joints, n (%)    
None 26 (62) 19 (58) 45 (60)
 1 8 (19) 6 (18) 14 (19)
 ≥ 2 8 (19) 8 (24) 16 (21)
  1. EHL, extended half-life; SD, standard deviation; SHL, short half-life
  2. ABR data were incomplete/missing for 2 patients
  3. Types of surgery included arthrocentesis, arthrodesis, arthroplasty, arthroscopy, or synovectomy
  4. #Bleed-related hospitalisation data were incomplete or missing for 13 patients