Table 3 Comparison of fractured and non-fractured patients
From: Osteogenesis Imperfecta: characterization of fractures during pregnancy and post-partum
OI female cohort 50 patients | Patients with Pregnancy-related Fractures* 12 patients | Patients with no fracture 38 patients | P* |
|---|---|---|---|
Type I, N (%) | 10/12 (83.3) | 18/24 (75.0) | 0.69 |
Genetically confirmed (%) | 8/12 (66.7) | 22/38 (57.9) | 0.74 |
Age at OI diagnosis (years, mean ± SD) | 18.4 ± 17.3 | 12.6 ± 14.3 | 0.24 |
Diagnosis in childhood, N (%) | 4/9 (44.4) | 19/27 (70.4) | 0.23 |
Number of fractures before pregnancy < 5, N (%) | 5/11 (45.5) | 10/38 (26.3) | 0.275 |
Number of fractures before pregnancy 5–10, N (%) | 2/11 (18.2) | 7/38 (18.4) | 1.0 |
Number of fractures before pregnancy 11–50, N (%) | 3/11 (27.3) | 19/38 (50.0) | 0.30 |
Number of fractures before pregnancy > 50, N (%) | 1/11 (9.1) | 3/38 (7.9) | 1.0 |
Blue sclera, N (%) | 11/11 (100) | 21/27 (77.8) | 0.15 |
Deafness, N (%) | 4/12 (36.4) | 8/30 (26.7) | 0.72 |
Joint Hyperlaxity, N (%) | 6/10 (60.0) | 14/28 (50.0) | 0.72 |
Scoliosis or kyphosis, N (%) | 5/10 (50.0) | 16/29 (55.2) | 1.0 |
Spine surgery or telescopic rods, N (%) | 1/11 (9.1) | 9/37 (25.7) | 0.42 |
Wheelchair or walking stick, N (%) | 2/11 (18.2) | 6/32 (18.75) | 1.0 |
Time between last fracture and pregnancy (years, mean ± SD) | 10.5 ± 8.1 | 10.1 ± 7.3 | 0.94 |
Bisphosphonates before pregnancy, N (%) | 2/12 (16.7) | 8/38 (21.1) | 1.0 |
Time since bisphosphonates (years, mean ± SD) | 12.5 ± 4.9 | 7.0 ± 4.5 | 0.18 |
Height (cm, mean ± SD) | 154.8 ± 10.9 | 153.4 ± 13.5 | 0.35 |
Weight (kg, mean ± SD) | 58.2 ± 12.2 | 56.6 ± 12.6 | 0.98 |
BMI (kg/m2, mean ± SD) | 24.8 ± 5.5 | 23.9 ± 4.7 | 0.52 |