Table 1 Summary of the causal effects of each trait on ALS via different MR methods

N SNPs

10

15

F statistics

954.49

1278.92

Simple median

OR (95% CI)

0.935 (0.756, 1.156)

0.981 (0.774, 1.242)

p value

0.535

0.872

Weighted median

OR (95% CI)

0.893 (0.750, 1.062)

0.982 (0.786, 1.227)

p value

0.201

0.872

MR Egger

OR (95% CI)

0.647 (0.447, 0.936)

0.839 (0.520, 1.352)

p value

0.050

0.483

Inverse variance weighted

OR (95% CI)

0.846 (0.744, 0.962)

0.941 (0.797, 1.111)

P value

0.011

0.471

MR Egger

intercept

0.025

0.006

p value

0.168

0.624

Cochran’s Q

Q

5.176278

12.014047

p value

0.82

0.61

MR-PRESSO

RSSobs

7.307

13.578

p value

0.774

0.632

outlier-corrected

NA

NA

MR Steiger

p value

0.0002

0.023

Statistical power

0.6

0.2