Skip to main content

Table 2 Patient’s bleeding score, clotting factor and aggregation data

From: RASopathies and hemostatic abnormalities: key role of platelet dysfunction

Patient Gene Bleeding score* Clotting factor (% of normal) Platelet response to**
V VII X XIII ADP Collagen Ristocetin AA
1 SOS1 7 67 48 64 47 2.8 0.8 1.1 0.4
2 SOS1 4 83.2 61 87 94.4 2.8 0.4 1.1 0.4
3 SOS1 3 55 81 76 73     
4 PTPN11 3 83 47.7 57 42 4 4 1.5 1
5 PTPN11 3 78.6 52 60 46 4 0.8 1.1 0.4
6 PTPN11 5 54 46 55   6 2 1.5 0.4
7 PTPN11 3 75 57 88 71 5 2 2 0.5
8 BRAF 3 85 58.5 74 29 1.2 0.4 1.1 0.4
9 MAP2K1 3 78 72    2 2 1.1 0.4
10 PTPN11 3 81 36 78 74 4 0.8 1.1 0.4
11 PTPN11 3 58 60.2 47.4   6 0.8 1.5 0.5
12 RIT1 3 50.2 46 50 50 5 0.8 1.5  
13 RIT1 3 55 44 50.5   5 1.2 1.2 0.5
14 PTPN11 3 117 86 62   4 0.4 1.1 0.4
  1. *These data are expression of 3 evaluations per patient
  2. **The response to platelet aggregation is the average of two repetitions