Table 1 EC50 for ADP, ristocetin, collagen, and AA for aggregation of PRP from controls and patients with RASopathies (mean ± SD of 2 different determinations)
From: RASopathies and hemostatic abnormalities: key role of platelet dysfunction
Stimulus | PRP from controls | PRP from patients with RASopathies | PRP from patients with pathologic bleeding scores | PRP from patients with normal bleeding score |
|---|---|---|---|---|
Adenosine diphosphate (ADP µM) | 1.84 ± 0.46 | 3.6 ± 1.2* | 4.5 ± 1.1 | 3.23 ± 1.1 |
Ristocetin (mg/ml) | 0.8 ± 0.3 | 1.1 ± 0.26 | 2 ± 0.3 | 1 ± 0.1 |
Collagen (µg/ml) | 0.42 ± 0.13 | 0.95 ± 0.88* | 2.5 ± 1 | 0.65 ± 0.3 |
Arachidonic acid (AA, mM) | 0.30 ± 0.01 | 0.4 ± 0.19 | 1 ± 0.2 | 0.4 ± 0.1 |