Skip to main content

Table 1  EC50 for ADP, ristocetin, collagen, and AA for aggregation of PRP from controls and patients with RASopathies (mean ± SD of 2 different determinations)

From: RASopathies and hemostatic abnormalities: key role of platelet dysfunction

Stimulus PRP from controls PRP from patients with RASopathies PRP from patients with pathologic bleeding scores PRP from patients with normal bleeding score
Adenosine diphosphate (ADP µM) 1.84 ± 0.46 3.6 ± 1.2* 4.5 ± 1.1 3.23 ± 1.1
Ristocetin (mg/ml) 0.8 ± 0.3 1.1 ± 0.26 2 ± 0.3 1 ± 0.1
Collagen (µg/ml) 0.42 ± 0.13 0.95 ± 0.88* 2.5 ± 1 0.65 ± 0.3
Arachidonic acid (AA, mM) 0.30 ± 0.01 0.4 ± 0.19 1 ± 0.2 0.4 ± 0.1
  1. *p < 0.05, significant difference between PRP of control individuals and that from patients with RASopathies