Table 1 Clinical features of ENKTL-Breast cases
Case | P/S | Age/sex | Side | Site | Size (cm) | Other sites involvement | BM | Stage | B-symptoms | LDH (IU/L) | EBV –DNA (copies/ml) | Concomitant diseases | Treatment | Follow-Up* |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | P | 31/F | R | areola | 5.7 × 3.5 | An isolated right axillary node involvement at the diagnosis of primary ENKTL-Breast | Normal | I | Yes | 311 | 1.81 × 104 | IgA nephropathy | GemxoD + Pe | Died (9 mo) |
2 | P | 26/F | R | UOQ | 4.0 × 3.0 | Both side of the lungs and the liver were involved one and a half months after the diagnosis of primary ENKTL-Breast | Normal | I | Yes | 787 | 1.40 × 103 | Chronic active hepatitis B | GDP | Died (3 mo) |
3 | P | 54/F | L | UOQ | 2.0 × 2.0 | None | Normal | I | No | NA | NA | NA | NA | LTF |
4 | S | 30/F | L | UOQ | 2.5 × 2.0 | Breast involvement appeared 20 months after the diagnosis of primary vagina ENKTL | Normal | IV | Yes | 449 | 1.30 × 104 | None | GLIDE + RT, followed by GMOX + Ca | Died (6 mo) |
5 | S | 57/F | R | UOQ | 1.0 × 1.0 | Breast involvement appeared 8 months after the diagnosis of primary nasal ENKTL | Normal | IV | Yes | 160 | Negative | None | VDLP, followed by SMILE + RT | Died (5 mo) |
6 | S | 46/F | R | UOQ | 2.8 × 2.0 | Breast involvement appeared 12 months after the diagnosis of primary nasal ENKTL | NA | IV | Yes | NA | NA | None | NA | LTF |
7 | S | 63/F | B | UOQ | R,2.0 × 2.0 L,5.0 × 3.0 | NA | NA | ND | Yes | NA | NA | None | NA | Died (11 mo) |
8 | S | 39/F | R | UOQ | 2.0 × 1.0 | Simultaneous involvement of GI tract and the breast | NA | IV | Yes | 982 | NA | Graves’ disease | NA | Died (2 mo) |