Alterations in brain morphology by MRI in adults with neurofibromatosis 1

Table 3 Correlation values and p-values of brainstem measurements with clinical and neuropsychometric assessments in adults with NF1

	Neuro. sev	ADD/ADHD	IQ	ACS	PC1	PC2	PC3
Clin. sev	− 0.06	− 0.56	− 0.24	− 0.13	0.21	− 0.17	0.21
Neuro. sev		0.43	− 0.38	− 0.21	− 0.51	− 0.16	− 0.20
ADD/ADHD			0.24	− 0.06	− 0.49	0.32	− 0.31
IQ				0.35	− 0.17	0.33	0.17
ACS					0.05	0.27	0.30
PC1						0.01	0.18
PC2							0.22

Top three brainstem PCs are correlated to neuropsychometric measurements (clinical severity, n = 70; clinical neurological severity, n = 70; clinical ADD/ADHD diagnosis, n = 50; IQ, n = 61; and Attention Comparison Score, n = 68). The correlation matrix combines the Pearson correlation and Spearman correlation (italicized) results. Abbreviations used in the table: Clin. Sev. = clinical NF1 severity, Neuro. Sev. = clinical neurological severity, ADD/ADHD = clinical Attention deficit hyperactivity disorder severity, IQ = intelligence quotient, ACS = Attention Comparison Score, and PC = principal component

ISSN: 1750-1172