From: A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease
Study identifier | Country | N | Mean age | VOC definition | # of reported VOCs/year | |||
---|---|---|---|---|---|---|---|---|
Mean | SD | Range | IQR | |||||
Le et al. [16] | Belgium | 139 | 21a | Hospitalization | 0/100 PYa,b | ‒ | ‒ | ‒ |
29.6/100 PYa,c | ||||||||
Donaldson et al. [22] | Jamaica | 50 | 18.5 | NR | 5.63/100 PYd | ‒ | ‒ | ‒ |
Upadhye et al. [23] | India | 75 | NR | NR | 9.7/100 PY | ‒ | ‒ | ‒ |
Lamarre et al. [24] | French West Indies | 49 | 11.9 | Hospitalization | 0.26e | 0.39 | ‒ | ‒ |
44 | 11.4 | 0.41f | ||||||
Willen et al. [25] | Multiple | 165 | 10 | Hospitalization | 0.27a | ‒ | ‒ | ‒ |
Asnani et al. [26] | Jamaica | 8504 | NR | Healthcare visit (OP or IP) to center; recorded in database | 0.4 | 0.7 | ‒ | ‒ |
DeBaun et al. [27] | U.S | 159 | 9a | Hospitalization and treatment with opioids | 0.46a | ‒ | ‒ | ‒ |
Boyd et al. [28] | U.S | 242 | 0.25 | Healthcare visit (OP or IP) to clinic | 0.47g | ‒ | ‒ | ‒ |
Rezende et al. [29] | Brazil | 461 | 9.2 | Healthcare visit (OP or IP) to center | 51/100 PY | ‒ | 48.9–53.4 | ‒ |
Schuchard et al. [30] | U.S | 35 | 0.6 | Healthcare visit (OP or IP) to center | 0.15h | ‒ | ‒ | ‒ |
13 | 1.6 | 0.9i | ||||||
17 | 3.0 | 0.52j | ||||||
Ceglie et al. [31] | Italy | 16 | 10.5 | Hospitalization at study center | 0.6k | ‒ | ‒ | ‒ |
23 | 10.3 | 1.6l | ||||||
Inati et al. [32] | Lebanon | 335 | 8.6 | Hospitalization | 0.6 | 0.6 | 0.04–2.4 | ‒ |
Jain et al. [33] | India | 833 | NR | Healthcare visit (OP or IP) to center | 64/100 PY | ‒ | ‒ | ‒ |
Lettre et al. [34] | Multiple | 1275 | 14.5 | NR | 0.7/PY | 1.4 | ‒ | ‒ |
Nimgaonkar et al. [35] | India | 137 | 14a | NR | 0.7 | ‒ | ‒ | ‒ |
Barner et al. [36] | U.S | 1190 | NR | Healthcare visit (OP, IP, or ED) | 4.1/5 year study period | 5 | ‒ | ‒ |
Willen et al. [37] | U.S | 197 | 11 | Hospitalization and treatment with opioids | 0.86 | ‒ | ‒ | ‒ |
Yates et al. [38] | Multiple | 15 | 9.6a | Hospitalization | 1.18a,m | ‒ | 0–1.94 | ‒ |
Joseph et al. [39] | U.S | 16,092 | 36.7 | Healthcare visit (OP, IP, or ED); Texas Medicaid claims | 1.2 | ‒ | ‒ | ‒ |
Leleu et al. [40] | France | 157 | 33a | Healthcare visit (OP, IP, or ED); French National Health Data System | 1.9n | ‒ | ‒ | ‒ |
Janecek et al. [41] | U.S | 66 | 38.8 | Healthcare visit (OP, IP, or ED) | 2o | ‒ | ‒ | ‒ |
Dave et al. [42] | India | 404 | 19 | Healthcare visit (OP or IP) to care system | 2.77 | ‒ | ‒ | ‒ |
Madu et al. [43] | Nigeria | 126 | 24.9 | Healthcare visit (OP or IP) to center | 3 | 4.8 | ‒ | ‒ |
Osunkwo et al. [18] | Multiple | 2145 | NR | Self-reported (patient survey; hospitalization, ED, managed at home) | 3a | ‒ | ‒ | 2–6 |
Latremouille-Viau et al. [44] | U.S | 18,287 | 28.5 | Healthcare visit (OP, IP, or ED); Medicaid and Medicare claims | 3.1p | ‒ | ‒ | |
15,431 | 48.2 | 3.4q | ||||||
Shah et al. [45] | U.S | 8521 | 32.9 | Healthcare visit (OP, IP, or ED); Medicaid claims | 3.31 | ‒ | ‒ | ‒ |
Desai et al. [46] | U.S | 44,033 | 15.7 | Healthcare visit (≥ 2 OP, or ≥ 1 IP, or ED); Medicaid claims | 3.71 | ‒ | ‒ | ‒ |
James et al. [19] | Multiple | 1513 | 24.1 | Self-reported (patient survey; hospitalization, ED, managed at home) | 5.2 | ‒ | ‒ | ‒ |
Alsultan et al. [47] | Saudi Arabia | 159 | 17.8 | Hospitalization for > 48 h | 5.6 | 5.7 | 0–36 | ‒ |
Andemariam et al. [20] | U.S | 384 | 30.1 | Self-reported (patient survey; hospitalization, ED, managed at home) | 7.1 | 5.7 | ‒ | ‒ |
Bronte-Hall et al. [48] | U.S | 149 | 33.2a | Healthcare visit (OP or IP) to center | 10.4 | ‒ | ‒ | ‒ |
McClish et al. [21] | U.S | 87 | 33.6 | Self-reported (patient diary) | 6.0/6 monthsk | ‒ | ‒ | ‒ |
139 | 34.5 | 6.8/6 monthsl | ||||||
Shome et al. [17] | Bahrain | 51 | 29.6 | Healthcare visit (OP or IP) to center | 18.2m | 17.5 | ‒ | ‒ |