Skip to main content

Table 3. DEGs inside the KEGG map “Pathways in cancer” identified in the most implicated signalings

From: Determining oncogenic patterns and cancer predisposition through the transcriptomic profile in Mitchell–Riley syndrome with heterotopic gastric mucosa and duodenal atresia: a case report

Signaling

Gene symbol

Gene name

Control mean counts

MRS mean counts

Fold change

q- value

PI3K signaling

BAD

BCL2 associated agonist of cell death

826.17

116.74

− 2.82

5.74 e−05

 

EGF

Epidermal growth factor

62.50

700.46

3.49

2.01 e−04

 

FGFR2

Fibroblast growth factor receptor 2

85.98

950.63

3.47

4.66 e−03

 

FLT3LG

fms related tyrosine kinase 3 ligand

92.37

0

− 4.90

4.48 e−02

 

HRAS

HRas proto− oncogene, GTPase

460.16

83.39

− 2.46

2.96 e−03

 

IGF1R

Insulin like growth factor 1 receptor

2771.65

11591.01

2.06

1.07 e−03

 

PDGFA

Platelet derived growth factor subunit A

29.57

150.10

2.37

1.98 e−02

 

PDGFRB

Platelet derived growth factor receptor beta

314.64

0

− 6.68

7.00 e−03

 

PIK3R3

Phosphoinositide− 3− kinase regulatory subunit 3

152.15

0

− 5.62

2.17 e−02

 

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

1679.24

6804.51

2.02

1.61 e−10

 

TGFA

Transforming growth factor alpha

951.89

50.03

− 4.25

2.30 e−04

ERK signaling

BRAF

B− Raf proto− oncogene, serine/threonine kinase

1366.54

9206.10

2.75

1.26 e−17

 

FGFR2

Fibroblast growth factor receptor 2

85.98

950.63

3.47

4.66 e−03

 

FLT3LG

fms related tyrosine kinase 3 ligand

92.37

0

− 4.90

4.48 e−02

 

HRAS

HRas proto− oncogene, GTPase

460.16

83.39

− 2.46

2.96 e−03

 

IGF1R

Insulin like growth factor 1 receptor

2771.65

11591.01

2.06

1.07 e−03

 

MAPK3

Mitogen− activated protein kinase 3

5762.75

1334.22

− 2.11

1.12 e−04

 

PDGFA

Platelet derived growth factor subunit A

29.57

150.10

2.37

1.98 e−02

 

PDGFB

Platelet derived growth factor subunit B

171.69

0

− 5.81

1.63 e−02

 

PDGFRB

Platelet derived growth factor receptor beta

314.64

0

− 6.68

7.00 e−03

 

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

1679.24

6804.51

2.02

1.61 e−10

 

TGFA

Transforming growth factor alpha

951.89

50.03

− 4.25

2.30 e−04

JAK− STAT signaling

EGF

Epidermal growth factor

62.50

700.46

3.49

2.01 e−04

 

FLT3LG

fms related tyrosine kinase 3 ligand

92.37

0

− 4.90

4.48 e−02

 

IFNAR2

Interferon alpha and beta receptor subunit 2

2464.19

83.39

− 4.89

6.69 e−11

 

IL12RB1

Interleukin 12 receptor subunit beta 1

2509.33

617.08

− 2.02

1.76 e−05

 

IL13RA1

Interleukin 13 receptor subunit alpha 1

5850.09

1184.12

− 2.30

2.81 e−05

 

IL15

Interleukin 15

240.69

50.03

− 2.26

4.34 e−02

 

IL2RB

Interleukin 2 receptor subunit beta

8781.96

733.82

− 3.58

8.80 e−08

 

IL2RG

Interleukin 2 receptor subunit gamma

6894.04

33.36

− 7.69

1.12 e−11

 

IL6R

interleukin 6 receptor

19003.48

4036.01

− 2.24

3.77 e−07

Calcium signaling

CAMK2D

Calcium/calmodulin dependent protein kinase II delta

1091.52

5470.29

2.32

6.63 e−11

 

EGF

Epidermal growth factor

62.50

700.46

3.49

2.01 e−04

 

PDGFA

Platelet derived growth factor subunit A

29.57

150.10

2.37

1.98 e−02

 

PDGFB

Platelet derived growth factor subunit B

171.69

0

− 5.81

1.63 e−02

 

PDGFRB

Platelet derived growth factor receptor beta

314.64

0

− 6.68

7.00 e−03

 

PRKCG

Protein kinase C gamma

3.07

166.78

5.79

6.10 e−08

 

TGFA

Transforming growth factor alpha

951.89

50.03

− 4.25

2.30 e−04

Other RAS signaling

EGF

Epidermal growth factor

62.50

700.46

3.49

2.01 e−04

 

HRAS

HRas proto− oncogene, GTPase

460.16

83.39

− 2.46

2.96 e−03

 

RALB

RAS like proto− oncogene B

7354.73

1417.61

− 2.38

4.91 e−09

 

RALGDS

Ral guanine nucleotide dissociation stimulator

959.68

16.68

− 5.85

4.33 e−04

 

RASSF1

Ras association domain family member 1

5456.91

717.14

− 2.93

1.40 e−13

 

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

1679.24

6804.51

2.02

1.61 e−10

WNT signaling

APC

APC regulator of WNT signaling pathway

1038.06

12174.73

3.55

1.22 e−15

 

FZD1

Frizzled class receptor 1

271.89

50.03

− 2.44

2.45 e−02

 

FZD6

Frizzled class receptor 6

64.00

517.01

3.01

1.78 e−05

 

LRP6

LDL receptor related protein 6

55.66

1400.93

4.64

7.96 e−06

 

WNT10B

Wnt family member 10B

229.22

0

− 6.22

9.03 e−03

  1. We highlighted the transcripts mean counts obtained after DESeq2 normalization, the fold changes computed as log2 (MRS mean counts/Control mean counts) and the q-value for each of the DEGs in our analysis that take place in the most implicated signalings in KEGG map “Pathways in cancer”. All values are rounded to the second decimal digit
Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172