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Table 1 Association of patient sociodemographic and clinical features with the family dermatology life quality index (FDLQI) scores

From: A multicenter study on quality of life of the “greater patient” in congenital ichthyoses

Variable Level N % Mean FDLQI score Median FDLQI score P value*
Overall   78 100 10.3 10.0  
Sex Male 35 44.9 11.0 10.0  
  Female 43 55.1 9.8 10.0 0.698
Age (years) < 18 48 61.5 10.0 10.0  
  ≥ 18 30 38.5 10.8 10.5 0.837
Clinical type LIa 68 87.2 10.2 10.0  
  CIEb 10 12.8 8.9 9.5 0.482
Mutated gene Undetermined 33 42.3 9.5 9.0  
  ABCA12 6 7.7 13.0 12.0  
  ALOX12B 10 12.8 11.7 12.0  
  ALOXE3 2 2.6 6.5 6.5  
  CYP4F22 5 6.4 7.6 8.0  
  NIPAL4 4 5.1 6.2 7.5  
  SDR9C7 0 0 NA NA  
  TGM1 18 23.1 10.3 10.0 0.163
Clinical severity scored Mild-moderate 56 71.8 9.2 8.0  
  Severe 22 28.2 13.1 13.0 0.003
Ear deformity NO 62 79.5 9.7 8.5  
  YES 16 20.5 12.8 13.0 0.016
Ectropion NO 53 67.9 9.9 9.0  
  YES 25 32.1 11.3 12.0 0.128
Eclabium NO 73 93.6 10.1 9.0  
  YES 5 6.4 14.0 13.0 0.069
Thick scales NO 41 52.6 9.9 9.0  
  YES 37 47.4 10.9 12.0 0.336
Dark scales NO 40 51.3 9.1 9.5  
  YES 38 48.7 11.6 12.0 0.094
Face scales NO 22 28.2 8.5 7.5  
  YES 56 71.8 11.0 11.0 0.039
Fissures NO 53 67.9 9.8 9.0  
  YES 25 32.1 11.4 11.0 0.209
PPKc NO 21 26.9 8.6 6.0  
  YES 57 73.1 11.0 11.0 0.041
Itch NO 9 11.5 9.6 11.0  
  YES 69 88.5 10.4 10.0 0.796
Recurrent infections NO 60 76.9 9.5 8.0  
  YES 18 23.1 13.0 13.0 0.004
Foul-smell NO 50 64.1 9.2 8.0  
  YES 28 35.9 12.4 12.0 0.009
Walking problems NO 66 84.6 10.0 9.0  
  YES 12 15.4 12.4 12.5 0.048
Visit/year 1 33 42.3 10.5 9.0  
  2 27 34.6 8.0 8.0  
  ≥ 4 18 23.1 13.6 13.0 0.007
Mother workse NO 39 55.7 10.4 9.0  
  YES 31 44.3 10.0 10.0 0.781
Father workse NO 9 13.2 7.4 8.0  
  YES 59 86.8 10.7 10.0 0.160
Workdays lost by caregivere NO 17 23.3 7.7 7.0  
  YES 56 76.7 11.2 10.0 0.033
  1. *Independent-samples Mann–Whitney U test for two samples, and Kruskal–Wallis 1-way ANOVA for 3 or more samples, P values < 0.05 are in bold
  2. aLI: lamellar ichthyosis, includes 2 patients with harlequin ichthyosis
  3. bCIE: congenital ichthyosiform erythroderma
  4. cPPK: palmoplantar keratoderma
  5. dClinical severity score: mild-moderate 0–5, severe ≥ 6 signs and/or symptoms
  6. eTotals may vary because of missing values