Table 1 Cancer occurrence in individuals ≤ 18 years old from our series. Each case corresponds to a unique proband
Cancer type | Number of probands | Age of onset | PTEN germline status |
|---|---|---|---|
Papillary thyroid cancer | 1 | 16 | p.(Lys6Argfs*4) |
1 | 16 | p.(Arg335*) | |
Follicular thyroid cancer | 1 | 14 | p.(Arg335*) |
Endometrial adenocarcinoma | 1 | 15 | p.(Cys136Arg) |
Ovarian endodermal sinus tumor | 1 | 6 | p.(Cys136Arg) |
Clear cell renal cell carcinoma | 1 | 18 | p.0? |
Hodgkin lymphoma | 1 | 18 | p.(Gln17*) |
Testicular mixed germ cell tumor | 1 | 18 | p.(Thr277Asnfs*21) |
Hodgkin lymphoma | 1 | 6 | WT |
Thyroid cancer (unspecified type) | 1 | 14 | WT |