Fig. 4

NCATS RD versus control total costs of 13 RD over 5-year time period. Total costs within the 5-year time period 2002–2007 calculated from the NCATSHCS database for 13 representative RD. Costs were calculated by taking the average PPPY cost by disease (Fig. 2b) and multiplying by the number of patients with the disease (Table 3). SCD sickle cell disease, MD muscular dystrophy, CF cystic fibrosis, HHT hereditary hemorrhagic teleangiectasia, BD Batten disease, LGS Lennox Gastaut syndrome, FSGS focal segmental glomerulosclerosis, EOE eosinophilic esophagitis, OI osteogenesis imperfecta, MNGIE mitochondrial neurogastrointestinal encephalopathy, Pheo pheochromocytoma, TA Takayasu’s arteritis