One hundred twelve cases of 46, XY DSD patients after initial gender assignment: a short-term survey of gender role and gender dysphoria

Table 4 THE comparison of CSRI score of 46, XY DSD patients with different etiologies (8–18 years)

Groups	Gender assignment n = 46	CSRI score (52 items)			Consistency *
Groups	Gender assignment n = 46	Masculine score M (QL–QU)	Feminine score M (QL–QU)	CSRI score M (QL–QU)	n (%)	p value
5α-RD2	Male (n = 22)	2.83 (2.65–3.18)	3.11 (2.67–3.32)	− 0.09 (− 0.45 to 0.32)	9 (40.9%)	0.587**
PAIS	Male (n = 7)	3.00 (2.89–3.11)	2.71 (2.37–2.95)	0.29 (− 0.05 to 0.36)	5 (71.4%)	0.428**
PAIS	Female (n = 1)	2.70 (–)	2.73 (–)	− 0.03 (–)	1 (100%)	–
CAIS	Female (n = 8)	2.58 (2.09–2.91)	2.86 (2.70–3.23)	− 0.28 (− 0.92 to 0.29)	4 (50%)	0.111***
NR5A1	Male (n = 5)	3.06 (2.51–3.19)	3.00 (2.63–3.11)	0.102 (− 0.12 to 0.22)	3 (60%)	1.000**
CYP17A1	Male (n = 1)	2.90 (–)	2.00 (–)	0.90 (–)	1 (100%)	–
CYP17A1	Female (n = 2)	3.15 (–)	3.60 (–)	− 0.45 (–)	2 (100%)	–
Control groups	Male (n = 35)	2.82 (2.47–3.06)	2.73 (2.40–3.00)	0.01 (− 0.20 to 0.30)	18 (51.4%)	–
Control groups	Female (n = 11)	2.23 (2.00–2.59)	2.70 (2.35–3.47)	− 0.42 (− 0.69 to − 0.34)	10 (90.9%)	–

5α-RD2, 5 alfa-reductase-2 deficiency; CAIS, complete androgen insensitivity syndrome; PAIS, partial androgen insensitivity syndrome; NR5A1, NR5AI gene mutation; CYP17A1, CYP17A1 gene mutation; CSRI, The Children's Sex Role Inventory; CSRI score = masculine score–feminine score, positive value (CSRI score > 0) indicates masculinity, negative value (CSRI score < 0) indicates feminization
^*Consistency of gender role and assigned gender
^**The chi-square test (Fisher exact probability method) was used to compare the consistency of gender role and assigned gender between 5α-RD2 deficiency, PAIS, NR5A1 and control males respectively, all p > 0.05
***The chi-square test (Fisher exact probability method) was used to compare the consistency of gender role and assigned gender between CAIS and control females (p = 0.111 > 0.05)

ISSN: 1750-1172