One hundred twelve cases of 46, XY DSD patients after initial gender assignment: a short-term survey of gender role and gender dysphoria

Table 3 The results of PSAI in 46, XY DSD children with different etiologies (2–7 years)

Compared to		Comparison of PSAI score (p value) **
5α-RD2 (M) n=33	--	1.000	1.000	0.000	0.000	1.000	0.000
PAIS (M) n=12	--	–	1.000	0.001	0.010	1.000	0.000
NR5A1 (M) n=7	--	–	–	0.000	0.000	0.936	0.000
CAIS (F) n=8	--	–	–	–	1.000	0.000	1.000
CYP17A1 (F) n=6	--	–	–	–	–	0.007	1.000
Control (M) n=52	--	–	–	–	–	–	0.000

M, male; F, female; 5α-RD2, 5 alfa-reductase-2 deficiency; CAIS, complete androgen insensitivity syndrome; PAIS, partial androgen insensitivity syndrome; NR5A1, NR5AI gene mutation; CYP17A1, CYP17A1 gene mutation; PSAI, pre-school Activities Inventory. PSAI score = (masculine score—feminine score) × 1.1 + 48.25. The higher the PSAI score obtained, the higher the degree of masculinity
*The Chi-Square test (Fisher exact probability method) was used to compare the consistency of the gender role and assigned gender between CYP17A1 gene mutation group (assigned as female) and control females, the result showed there was no statistical difference between them (p = 0.30 > 0.05)
**The Kruskal–Wallis H test was used to compare the PSAI score between different etiologies groups and control groups. There was statistical difference between them (Chi-Square = 71.168, p < 0.001).The Mann–Whitney adjusted by Bonferroni Pairwise comparisons were performed by U-test: the PSAI score of patients with 5α-RD2 deficiency, PAIS, and NR5A1 gene mutation (assigned as male) were higher than those with CAIS and CYP17A1 gene mutation (assigned as female) (p < 0.05). The PSAI score of patients with CAIS and CYP17A1 gene mutation were similar to the control females (all p > 0.05)

ISSN: 1750-1172