Fig. 4
From: In-depth phenotyping for clinical stratification of Gaucher disease
Cumulative hazard for first osteonecrosis event according to treatment status. The hazard or risk of having a first osteonecrosis event after presentation of Gaucher disease was significantly lower after starting enzyme replacement therapy (ERT) than before (hazard ratio of 0.20; 95% CI 0.11–0.38; p < 0.001). The effects of substrate reduction therapy (SRT) and bone marrow transplantation (BMT) was difficult to assess owing to the low sample size (nine and two patients received SRT or BMT as first treatment, respectively). Of the two patients with BMT, one had their first episode of osteonecrosis after the procedure. Horizontal axis shows time in years after presentation of Gaucher disease