|
Phenotypic characteristic variable versus reference category
|
Unadjusted HR (95% CI)
|
P-value
|
Adjusted HR (95% CI)
|
P-value
|
|---|
|
Geographic origin
| | | | |
|
Asian versus European
|
3.5 (1.3–9.2)
|
0.011
|
5.0 (1.8–13.4)
|
0.001
|
|
African versus European
|
3.4 (0.4–25.3)
|
0.24
|
3.6 (0.5–24.9)
|
0.20
|
|
American versus European
|
2.4 (0.8–7.3)
|
0.11
|
3.2 (1.03–9.6)
|
0.044
|
|
Sex
| | | | |
|
Male versus female
|
1.4 (0.7–2.6)
|
0.27
| | |
|
Age at onset
| | | | |
|
≥ 18 versus < 18 years
|
0.44 (0.23–0.85)
|
0.014
|
0.21 (0.06–0.79)
|
0.021
|
|
Consanguinity
| | | | |
|
Present vs Absent
|
1.5 (0.7–3.0)
|
0.31
| | |
|
Mutated gene
| | | | |
|
EPM2B versus EPM2A
|
1.1 (0.5–2.5)
|
0.75
|
1.3 (0.5–3.0)
|
0.59
|
|
Compound heterozygosity
| | | | |
|
Present vs Absent
|
0.8 (0.4–1.7)
|
0.63
| | |
|
Type of onset
| | | | |
|
Motor versus Epileptic
|
1.9 (0.9–4.1)
|
0.091
|
1.4 (0.7–3.0)
|
0.36
|
|
Cognitive versus Epileptic
|
1.0 (0.4–4.0)
|
0.96
|
0.8 (0.3–2.0)
|
0.59
|
- Bold means statistically significant value (P < 0.005)
