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Table 3 Factors associated with shorter survival

From: Natural history of Lafora disease: a prognostic systematic review and individual participant data meta-analysis

Phenotypic characteristic variable versus reference category Unadjusted HR (95% CI) P-value Adjusted HR (95% CI) P-value
Geographic origin     
Asian versus European 3.5 (1.3–9.2) 0.011 5.0 (1.8–13.4) 0.001
African versus European 3.4 (0.4–25.3) 0.24 3.6 (0.5–24.9) 0.20
American versus European 2.4 (0.8–7.3) 0.11 3.2 (1.03–9.6) 0.044
Sex     
Male versus female 1.4 (0.7–2.6) 0.27   
Age at onset     
 ≥ 18 versus < 18 years 0.44 (0.23–0.85) 0.014 0.21 (0.06–0.79) 0.021
Consanguinity     
Present vs Absent 1.5 (0.7–3.0) 0.31   
Mutated gene     
EPM2B versus EPM2A 1.1 (0.5–2.5) 0.75 1.3 (0.5–3.0) 0.59
Compound heterozygosity     
Present vs Absent 0.8 (0.4–1.7) 0.63   
Type of onset     
Motor versus Epileptic 1.9 (0.9–4.1) 0.091 1.4 (0.7–3.0) 0.36
Cognitive versus Epileptic 1.0 (0.4–4.0) 0.96 0.8 (0.3–2.0) 0.59
  1. Bold means statistically significant value (P < 0.005)