Table 2 CSF CHIT1 levels in nusinersen-naïve SMA patients
From: Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy
All SMA patients (n = 79) | Adult SMA patients (n = 58) | Pediatric SMA patients (n = 21) | Controls (n = 30) | |
|---|---|---|---|---|
CSF CHIT1 (pg/mL), median (IQR) | 1787 (959–2866) | 1838 (1035–3133) | 1294 (883–2657) | 563 (563–971) |
Range | 563–9810 | 563–9810 | 563–8341 | 563–3058 |
Below LLOQ, n (%) | 12 (15) | 8 (14) | 4 (19) | 17 (57) |