Clinical features and treatment efficacy for IgG4-related thyroiditis

Han, Xinxin; Zhang, Panpan; Li, Jieqiong; Liu, Zheng; Lu, Hui; Luo, Xuan; Pan, Boju; Lian, Xiaolan; Zeng, Xuejun; Zhang, Wen; Zeng, Xiaofeng

doi:10.1186/s13023-021-01942-x

Orphanet Journal of Rare Diseases

Table 5 Clinical features of 14 IgG4-related thyroiditis

From: Clinical features and treatment efficacy for IgG4-related thyroiditis

Sex/age	Disease duration (m)	Symptoms	Affected organs	Diagnosis	Serum IgG4 (mg/L)	Thyroid US	Baseline RI	Treatment
F/52	108	Goiter, hardened thyroid, lymph node swelling, abdominal pain, arthralgia	LN, thyroid	Possible	7100	Diffuse thyroid enlargement	4	GCs 30 mg qd LS
F/56	120	Goiter, hardened thyroid, lower limb edema, chills	Kidney, pituitary, sinus, thyroid	Definite	5300	Diffuse thyroid enlargement	10	GCs 40 mg qd MMF 0.75 g bid LS
M/26	3	Goiter, hardened thyroid, neck compression	Pancreas, thyroid	Definite	11,400	Diffuse thyroid enlargement	4	GCs 50 mg qd LS
F/54	120	Goiter, hardened thyroid, neck compression, lymph node swelling	LN, thyroid	Definite	2600	Diffuse thyroid enlargement	4	GCs 40 mg qd LS
M/58	6	Goiter, hardened thyroid, neck compression	Thyroid, liver, LN	Definite	3130	Diffuse thyroid enlargement	6	GCs 40 mg qd LS
F/52	7	Goiter, hardened thyroid, neck compression, dyspnea	Thyroid	Possible	2210	Diffuse thyroid enlargement with nodular changes of the left lobe	4	Iguratimod 25 mg bid
M/31	36	Goiter, hardened thyroid	Thyroid	Definite	1850	Goiter with low-level echo in the middle of the left lobe	2	LS
M/36	5	Goiter, hardened thyroid, fatigue	Thyroid	Possible	3250	Diffuse thyroid enlargement	2	GCs 40 mg qd LS
F/16	48	Goiter, hardened thyroid	Thyroid	Possible	5130	Diffuse thyroid enlargement	2	LS
F/59	24	Goiter, hardened thyroid, neck compression, lower limb edema	Thyroid	Definite	4370	Diffuse thyroid enlargement, calcification within the right lobe	2	Iguratimod 25 mg bid LS
M/29	96	Goiter, hardened thyroid	Thyroid	Possible	16,000	Diffuse thyroid enlargement	2	Iguratimod 25 mg bid
M/61	96	Goiter, hardened thyroid, LG enlargement	SMG, LG, lung, LN, thyroid	Possible	20,600	Diffuse thyroid enlargement with solid nodules within the left lobe	10	GCs 30 mg qd CTX 100 mg qd LS
M/41	8	Goiter, hardened thyroid, nausea and vomiting	PAO, pachymeningitis, sinus, thyroid	Possible	1548	Diffuse thyroid enlargement	10	GCs 60 mg qd CTX 100 mg qd TMX 10 mg bid LS
F/28	6	Goiter, hardened thyroid	Thyroid	Possible	7540	Diffuse thyroid enlargement Multiple flaky hypoechoic areas	2	LS

Normal range of serum IgG4: 80-1400 mg/L
US: ultrasound; Baseline RI represented baseline IgG4-RD responder index; LN: lymph nodes; SMG: submandibular gland; LG: lacrimal gland; PAO: periaortitis; GCs: glucocorticoids. CTX: Cyclophosphamide. MMF: Mycophenolate Mofetil. TMX: tamoxifen. LS: levothyroxin sodium

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ISSN: 1750-1172

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