Fig. 3
From: Clinical, molecular and glycophenotype insights in SLC39A8-CDG
MALDI-TOF MS profiles of permethylated serum N-glycans from the studied SLC39A8-CDG patients compared to a reference control. Serum N-glycan analysis in a paediatric representative control (a). N-glycan analyses on this study’s patients, showing increased amount of hyposialylated and/or hypogalactosylated biantennary and triantennary structures and an overall increase in fucosylation (b–d). The observed increases are outlined by red marks. Glycan structures were assigned following consortium for functional glycomics guidelines: N-acetylglucosamine, blue square; mannose, green circle; galactose, yellow circle; sialic acid, purple lozenge; fucose, red triangle