Fig. 1

RASopathy genes. Neurofibromatosis type I, Legius and Costello syndromes, intellectual disability and people with autism spectrum disorder (Autism), and capillary malformation-arteriovenous malformation syndrome (CM-AVM) have just one protein as the cause of the disease, whereas the rest of RASopathies may be triggered by several defective proteins. In more than 90% of cases juvenile myelomonocytic leukemia (JMML) (not illustrated in the figure) is driven by alterations in PTPN11, NRAS, CBL, KRAS and NF1 genes