Table 3 Everolimus/Sirolimus-related adverse events
Sirolimus n = 33 (%) | Everolimus n = 91 (%) | P-value All grades | |||
|---|---|---|---|---|---|
All grades | Grade 3–4 | All grades | Grade 3–4 | ||
Gastrointestinal | |||||
Mucositis oral | 30 (91) | 4 (12) | 89 (98) | 11 (12) | 0.23 |
Diarrhea | 4 (12) | 0 | 5 (5) | 0 | 0.39 |
Vomiting | 0 | 0 | 3 (3) | 0 | 0.69 |
Constipation | 2 (6) | 0 | 1 (1) | 0 | 0.35 |
Gynaecological | |||||
Irregular menstruation (female) | 7 (30) | 3 (13) | 25 (44) | 9 (15) | 0.27 |
Metabolic | |||||
Hypertriglyceridemia | 11 (33) | 0 | 30 (33) | 0 | 0.97 |
Cholesterol high | 4 (12) | 0 | 11 (12) | 0 | 0.76 |
Proteinuria | 2 (6) | 0 | 8 (9) | 0 | 0.90 |
ALP increased | 4 (12) | 0 | 8 (9) | 0 | 0.83 |
GGT increased | 2 (6) | 0 | 5 (5) | 0 | 0.75 |
Hypophosphatemia | 0 | 0 | 3 (3) | 0 | 0.69 |
Infection | |||||
Upper respiratory infection | 11 (33) | 0 | 22 (24) | 0 | 0.31 |
Pneumonitis | 4 (12) | 2 (6) | 5 (6) | 3 (3) | 0.39 |
Urinary tract infection | 4 (12) | 0 | 5 (6) | 0 | 0.39 |
Dermatology | |||||
Rash acneiform | 6 (18) | 0 | 16 (18) | 3 (3) | 0.94 |
Constitutional symptoms | |||||
Abdominal pain | 4 (12) | 0 | 11 (12) | 0 | 0.76 |
Headache | 4 (12) | 0 | 3 (3) | 0 | 0.15 |
Malaise | 2 (6) | 0 | 3 (3) | 0 | 0.86 |
Soft tissues | |||||
Peripheral oedema | 4 (12) | 2 (6) | 3 (3) | 0 | 0.15 |
Blood | |||||
Neutrophil count decreased | 2 (6) | 0 | 3 (3) | 0 | 0.86 |
Lymphocyte count decreased | 0 | 0 | 3 (3) | 0 | 0.69 |
Anemia | 2 (6) | 0 | 1 (1) | 0 | 0.35 |