Table 3 Main immunohematological characteristics of Dercum’s disease (DD) and Roch-Leri lipomatosis (LMS) groups compared to the lean control group
Characteristics at diagnosis | Dercum (n = 9) | LMS (n = 11) | Lean controls (n = 18) | p DD versus Lean | p LMS versus Lean | p DD versus LMS |
|---|---|---|---|---|---|---|
History | ||||||
Dysimmune disorders (%; n/N) | 22% (2/9) | 45% (5/11) | 0% (18/18) | – | – | – |
Paraclinical | ||||||
Hemoglobin (g/dL) | 14.3 [12.5–15.4] | 14.6 [12–15.4] | 15 [12.1–17.3] | 0.07 | 0.41 | 0.46 |
Platelets (103/mm3) | 266 [211–310] | 220 [104–255] | 210 [176–338] | 0.005 | 0.39 | 0.10 |
Leukocytes (103/mm3) | 7.8 [5–9.1] | 5.8 [5.2–9.8] | 5.4 [4.3–11.1] | 0.02 | 0.49 | 0.19 |
CRP (mg/L) | 3 [3–18] | 3 [3–10] | 3 [3, 4] | 0.11 | 0.65 | 0.52 |
Leukocyte differential: (/mm3) | ||||||
Lymphocytes | 1939 [1100–2000] | 1832 [600–2300] | 1950 [1600–3300] | > 0.9 | 0.72 | 0.63 |
Monocytes | 500 [500–700] | 400 [400–600] | 400 [300–900] | 0.21 | > 0.9 | 0.33 |
Nuclear neutrophils | 5200 [2600–10000] | 3300 [2500–4600] | 2800[1200–3260] | 0.50 | 0.35 | 0.14 |
Eosinophils | 150 [0–300] | 100 [0–500] | 100 [0–1600] | > 0.9 | 0.26 | 0.20 |
Basophils | 52 [30–100] | 19 [0–37] | 0 [0–14] | 0.001 | 0.57 | 0.001 |
Lymphocytes subpopulations (n/N) | (5/9) | (7/11) | (18/18) | |||
CD3+ | 1420 [1105–1904] | 867 [513–1584] | 1444[913–2607] | > 0.9 | 0.009 | 0.04 |
CD4+ | 1255 [790–1710] | 636.5 [328–922] | 866 [367–1653] | 0.23 | 0.048 | 0.03 |
CD8+ | 479 [454–788] | 227[140–310] | 546 [284–943] | > 0.9 | 0.014 | 0.007 |
B Lymphocytes | 204.5 [140–760] | 227 [101–310] | 211 [103–528] | > 0.9 | > 0.9 | 0.93 |
NK Lymphocytes | 207.5 [40–225] | 210 [124–300] | 292 [136–450] | 0.049 | 0.31 | 0.53 |