Fig. 2

Spectrum of clinical presentations in Langerhans Cell Histiocytosis (LCH). A–D Different skin lesions. E, F Cranial bone lesions on single and multiple sites. G LCH patient with cranial and mandibular bone lesions and swollen eyes. H, I Lung lesions. J Pituitary lesions (arrow). K Skin lesions at birth. L Nail lesions. M–O PET-CT images showed a single bone lesion involving the right tibia; multiple bone lesions; multiple-system lesions involving the bones, lung and lymph nodes (arrow)