Skip to main content
Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Enzyme replacement therapy and hematopoietic stem cell transplant: a new paradigm of treatment in Wolman disease

Fig. 5

Patient 5 liver biopsies pre and post HCT showing improvement over time. a–c were pre HCT, taken in 2017, 2018 and 2019 respectively. d Was taken in 2020, 12 months after HCT. a–c demonstrate worsening portal tract foamy macrophage accumulation, including many containing abundant cholesterol clefts (arrowheads); there is also worsening hepatocellular ballooning (arrows) and fibrosis. d Demonstrates a dramatic improvement in histological appearances after HCT (all images haematoxylin and eosin stained FFPE sections, × 400 original magnification)

Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172