Fig. 1

Metabolic control in dependence of OHCbl substitution. a Patient 1, b patient 2, c patient 3, and d patient 4. Concentrations of total homocystein (tHcy) in plasma [µmol/l] over the time are depicted by a rhombus. 1 mg OHCbl was injected IV (intravenous), IM (intramuscular) or SQ (subcutaneous), respectively, with varying frequency, demonstrated by the grey area (QW weekly, Q2W every 2 weeks, Q3W every 3 weeks, BIW twice a week, TIW three times a week, FIW five times a week, QD daily, E5D every 5 days)