From: French recommendations for the management of systemic sclerosis
a. HBP ≥ 140/90 mmHg (or increase of systolic BP ≥ 30 mmHg or diastolic BP ≥ 20 mmHg) obtained on two different measurements with a minimum separation of 5 min, without other explanation than the SSc |
b. Acute renal injury, without other explanation than the SSc AKI according to the KDIGO classification: more than 50% increase of serous creatinine from the reference value within the preceding 7 days or an absolute increase of 26.5 µmol/l (≥ 0.3 mg/dl) in 48 h |
c. Thrombotic microangiopathy  New or aggravated anemia without other explanation  Schizocytes  Thrombopenia ≤ 100,000/mm3 confirmed on a smear  Signs of hemolysis: elevated LDH, low haptoglobin, increased reticulocytes  Negative antiglobulin test |
Target organ dysfunction  Hypertensive retinopathy  Hypertensive encephalopathy  Pulmonary edema  Acute pericarditis |
Anomalies suggestive of renal biopsy (fibrinous thrombi, fibrinoid necrosis, glomerular collapse, onion bulb proliferation in pre-glomerular arterioles and arch arteries) |