Fig. 4

Splenomegaly during the observation period. Spleen volumes in Multiples of Normal (MN) for the pediatric (a) and adult (b) cohorts at baseline (BL), year 1, and final assessment. Severity of splenomegaly cutoffs are indicated by solid lines where mild is < 5 MN, moderate is ≥ 5 and ≤ 15 MN, and severe is > 15 MN [15]